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E1001

Sigma-Aldrich

Ethisterone

≥99% (HPLC)

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Synonym(s):
17α-Ethynyltestosterone, 17β-Hydroxy-4,17α-pregnen-20-yn-3-one, 4,17α-Pregnen-17β-ol-20-yn-3-one
Empirical Formula (Hill Notation):
C21H28O2
CAS Number:
Molecular Weight:
312.45
Beilstein/REAXYS Number:
1889895
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

sterility

non-sterile

assay

≥99% (HPLC)

form

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

technique(s)

cell culture | mammalian: suitable

mp

263-269 °C (lit.)

solubility

chloroform: methanol (1:1): 20 mg/mL, clear to slightly hazy, colorless to light yellow

originator

Novartis

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@@]4(C)[C@H]3CC[C@@]4(O)C#C

InChI

1S/C21H28O2/c1-4-21(23)12-9-18-16-6-5-14-13-15(22)7-10-19(14,2)17(16)8-11-20(18,21)3/h1,13,16-18,23H,5-12H2,2-3H3/t16-,17+,18+,19+,20+,21+/m1/s1

InChI key

CHNXZKVNWQUJIB-CEGNMAFCSA-N

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1 of 4

This Item
H5752N4128P8629
vibrant-m

E1001

Ethisterone

vibrant-m

H5752

17α-Hydroxyprogesterone

vibrant-m

N4128

19-Norethindrone

vibrant-m

P8629

5β-Pregnane-3α,17α,20α-triol

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

-

form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

drug control

-

drug control

-

drug control

-

originator

Novartis

originator

-

originator

-

originator

-

General description

Ethisterone is a progestogen. It is a danazol derivative.

Application

Ethisterone has been used as a component in Dulbecco′s modified eagle medium (DMEM) to culture the transfected COS-7 cell for transient transfection assay and gene transfection assay.

Biochem/physiol Actions

Ethisterone acts as a progestational agent. It is consumed by pregnant mothers to prevent miscarriage.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazardEnvironment

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1A

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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Junsu Kang et al.
Developmental cell, 27(1), 19-31 (2013-10-19)
Precise spatiotemporal regulation of signaling activators and inhibitors can help limit developmental crosstalk between neighboring tissues during morphogenesis, homeostasis, and regeneration. Here, we find that the secreted Wnt inhibitor Dkk1b is abundantly produced by dense regions of androgen-regulated epidermal tubercles
Cloning and expression analysis of androgen receptor gene in chicken embryogenesis
Katoh H, et al.
Febs Letters, 580(6), 1607-1615 (2006)
Ambiguous Genitalia in the Newborn
Avery's Diseases of the Newborn, 1286-1306 (2012)
Evolutionary History and Functional Characterization of Androgen Receptor Genes in Jawed Vertebrates
Ogino Y, et al.
Endocrinology, 150(12), 5415-5427 (2009)
Hypothalamic, pituitary and sex hormones
Clinical Pharmacology, 596-614 (2012)

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