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F2552

Sigma-Aldrich

Formestane

solid

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Synonym(s):
4-Hydroxyandrost-4-ene-3,17-dione, CGP-32349
Empirical Formula (Hill Notation):
C19H26O3
CAS Number:
Molecular Weight:
302.41
MDL number:
PubChem Substance ID:
NACRES:
NA.25

biological source

synthetic (organic)

Quality Level

assay

≥98% (HPLC)

form

solid

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

solubility

chloroform: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

application(s)

forensics and toxicology
veterinary

storage temp.

2-8°C

SMILES string

C[C@]12CC[C@H]3[C@@H](CCC4=C(O)C(=O)CC[C@]34C)[C@@H]1CCC2=O

InChI

1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1

InChI key

OSVMTWJCGUFAOD-KZQROQTASA-N

Gene Information

human ... CYP19A1(1588)

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1 of 4

This Item
A3009P6149SMB01374
Formestane solid

F2552

Formestane

4-Androsten-11β-ol-3,17-dione

A3009

4-Androsten-11β-ol-3,17-dione

Progesterone γ-irradiated, BioXtra, suitable for cell culture

P6149

Progesterone

biological source

synthetic (organic)

biological source

-

biological source

synthetic (organic)

biological source

synthetic

Gene Information

human ... CYP19A1(1588)

Gene Information

-

Gene Information

human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

Gene Information

-

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

form

solid

form

powder

form

powder

form

solid

solubility

chloroform: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

chloroform: 49-51 mg/mL, clear, colorless to faintly yellow

solubility

chloroform: 50 mg/mL, clear, colorless to light yellow

solubility

-

Biochem/physiol Actions

Aromatase inhibitor used as an anti-cancer agent against estrogen-dependent tumors.

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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The aromatase inhibitor formestane (4-hydroxy-androst-4-ene-3,17-dione, F) is prohibited in sports by the World Anti-Doping Agency (WADA). F possesses only weak androgenic properties and is presumed to be employed in order to suppress estrogen production during the illicit intake of anabolic
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Rapid communications in mass spectrometry : RCM, 22(24), 4147-4157 (2008-11-26)
Studies have shown that the administration of androstenedione (ADIONE) significantly increases the urinary ratio of testosterone glucuronide to epitestosterone glucuronide (T/E) - measured by gas chromatography/mass spectrometry (GC/MS) - in subjects with a normal ( approximately 1) or naturally high
L R Wiseman et al.
Drugs & aging, 9(4), 292-306 (1996-10-01)
Formestane (4-hydroxyandrostenedione) is an aromatase inhibitor which significantly reduces plasma levels of estrogen and has shown antitumour activity in postmenopausal women with breast cancer. Objective response rates in heavily pretreated patients with advanced breast cancer generally range between 20 and
L R Wiseman et al.
Drugs, 45(1), 66-84 (1993-01-01)
Formestane (4-hydroxyandrostenedione) is an effective and competitive inhibitor of aromatase, the enzyme responsible for the conversion of androgens to estrone and estradiol. Significant reductions in plasma estradiol levels are observed following intramuscular administration of formestane to postmenopausal women with advanced

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