G1049
Poly-L-γ-glutamic acid sodium salt
suitable for drug transporter assays, Mol wt ≥750,000
Synonym(s):
γ-PGA
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Product Name
Poly-L-γ-glutamic acid sodium salt,
form
powder
Quality Level
mol wt
≥750,000
technique(s)
drug transporter assay: suitable
color
white to off-white
application(s)
cell analysis
storage temp.
−20°C
Related Categories
Application
High molecular weight poly-γ-glutamic acid (γPGA) was found to increase levels of NK cell-mediated cytotoxicity and INF-γ secretion in C57BL/6 mice.[1] Biodegradable γ-PGA nanoparticles have been evaluated for use as antigen delivery carriers[2] and delivery of influenza virus hemagglutin (HA) vaccine.[3] Additional life science applications for γ-PGA include uses in biodegradable fibers and nanofiber sheets, hydrogels, and cryoprotectants.[4][5][6]
Other Notes
High molecular weight poly-γ-glutamic acid is a polymer of glutamic acid connected by amide linkages between α-amino and γ-carboxylic acid groups. γ-PGA is produced by fermentation in Bacillus species. The subunits are predominantly L-isomer.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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The utility of poly(γ-glutamic acid) nanoparticles as antigen delivery carriers in dendritic cell-based cancer immunotherapy.
Matsuo, K., et al.
Biological & Pharmaceutical Bulletin, 33, 2007-2007 (2010)
Shigefumi Okamoto et al.
Vaccine, 27(42), 5896-5905 (2009-08-04)
Adding poly(gamma-glutamic acid) nano-particles (gamma-PGA-NPs), a safe, natural material, to subcutaneous immunization with influenza virus hemagglutinin (HA) vaccine increases the protective immune responses against influenza virus in mice. Here, we examined whether intranasal administration of the HA vaccine with gamma-PGA-NPs
Ilaria Massaiu et al.
Microbial cell factories, 18(1), 3-3 (2019-01-11)
Genome-scale metabolic models (GEMs) allow predicting metabolic phenotypes from limited data on uptake and secretion fluxes by defining the space of all the feasible solutions and excluding physio-chemically and biologically unfeasible behaviors. The integration of additional biological information in genome-scale models
Preparation and evaluation of poly(γ-glutamic acid)-based anti-adhesion membranes.
Kim, Y.-A., et al.
Key Engineering Materials, 342, 225-225 (2007)
I L Shih et al.
Bioresource technology, 79(3), 207-225 (2001-08-14)
This review article deals with the chemistry and biosynthesis of poly-(gamma-glutamic acid) (gamma-PGA) produced by various strains of Bacillus. Potential applications of gamma-PGA as thickener, cryoprotectant, humectant, drug carrier, biological adhesive, flocculant, or heavy metal absorbent, etc. with biodegradability in
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