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G5630

Sigma-Aldrich

Gly-Gly-Gly-Gly-Gly-Gly

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Synonym(s):
Hexaglycine
Empirical Formula (Hill Notation):
C12H20N6O7
CAS Number:
Molecular Weight:
360.32
MDL number:
PubChem Substance ID:
NACRES:
NA.26

form

solid

Quality Level

color

white

mp

314.5 °C

application(s)

peptide synthesis

storage temp.

−20°C

SMILES string

NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(O)=O

InChI

1S/C12H20N6O7/c13-1-7(19)14-2-8(20)15-3-9(21)16-4-10(22)17-5-11(23)18-6-12(24)25/h1-6,13H2,(H,14,19)(H,15,20)(H,16,21)(H,17,22)(H,18,23)(H,24,25)

InChI key

XJFPXLWGZWAWRQ-UHFFFAOYSA-N

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This Item
C6154G3882G3002
Z-Gln-Gly γ-glutamyl donor substrate

Sigma-Aldrich

C6154

Z-Gln-Gly

Gly-Gly-Gly-Gly

Sigma-Aldrich

G3882

Gly-Gly-Gly-Gly

Gly-Pro

Sigma-Aldrich

G3002

Gly-Pro

color

white

color

-

color

white to off-white

color

white

mp

314.5 °C

mp

-

mp

300 °C

mp

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

application(s)

peptide synthesis

application(s)

-

application(s)

peptide synthesis

application(s)

-

Application

Hexaglycine and capped hexaglycine are used in physicochemical studies of peptide structure dynamics. Hexaglycine is used as a model compound in development of peptide quantitation and separation methods.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Sigma-Aldrich

L9026

Lys-Lys-Lys-Lys

Triglycine United States Pharmacopeia (USP) Reference Standard

USP

1686386

Triglycine

Leu-Leu-Leu ≥90% (elemental analysis)

Sigma-Aldrich

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Voislav Blagojevic et al.
The Analyst, 135(6), 1456-1460 (2010-05-26)
A novel method is presented for the quantitation of peptides based on their methylation by in vacuo chemical reaction with methyl iodide. Samples of two small peptides, hexaglycine and pentaalanine, were labeled with CH(3)I and CD(3)I, representing the "unknown" and
Joshua A Plumley et al.
The journal of physical chemistry. B, 115(6), 1562-1570 (2011-01-26)
We compare the energies and enthalpies of inter-action of three- and seven-stranded capped polyglycine aggregates in both the pleated and rippled antiparallel and parallel β-sheet structures as well as the collagenic (three-strand) or polyglycine II-like (seven-strand) forms using density functional
Punam Dalai et al.
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 47(4), 427-452 (2016-10-21)
On the Hadean-Early Archean Earth, the first islands must have provided hot and dry environments for abiotically formed organic molecules. The heat sources, mainly volcanism and meteorite impacts, were also available on Mars during the Noachian period. In recent work
Brett Harper et al.
Journal of the American Society for Mass Spectrometry, 25(10), 1716-1729 (2014-07-30)
It is shown that y-type ions, after losing C-terminal H2O or NH3, can lose an internal backbone carbonyl (CO) from different peptide positions and yield structurally different product fragment ions upon collision-induced dissociation (CID). Such CO losses from internal peptide

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