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G8044

Sigma-Aldrich

Anti-phospho-GATA4 (pSer105) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
MFCD06798487
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 46 kDa

species reactivity

mouse

packaging

pkg of (1 vl = 100ul)

technique(s)

western blot: 1:500

UniProt accession no.

Q08369

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... GATA4(2626)
mouse ... Gata4(14463)
rat ... Gata4(54254)

Immunogen

Anti-phospho-GATA4 (pSer105) antibody produced in rabbit is suitable for western blotting at working dilution 1:500.
synthetic phosphopeptide derived from the region of GATA-4 that contains serine 105.

Biochem/physiol Actions

GATA-4 has a molar mass of 46kDa and belongs to the GATA family of zinc finger-containing transcription factors. It is involved in the development of cardiac hypertrophy and remodeling. It plays a crucial role in regulating basal and agonist or stress-induced gene expression in cardiac and smooth muscle cell types. Upon agonist stimulation via MEK1-ERK1/2, and weakly via JNK or p38 MAPKs, Ser105 of GATA-4 is phosphorylated. Phosphorylation of GATA-4 by hepatocyte growth factor facilitates cell survival in cardiac muscle cells via MEK/ERK-dependent signaling pathway.

Physical form

Solution in Dulbecco′s PBS, pH 7.3 with 1 mg/mL BSA and 0.05% Sodium Azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Q Liang et al.
Molecular and cellular biology, 21(21), 7460-7469 (2001-10-05)
The zinc finger-containing transcription factor GATA4 has been implicated as a critical regulator of multiple cardiac-expressed genes as well as a regulator of inducible gene expression in response to hypertrophic stimulation. Here we demonstrate that GATA4 is itself regulated by
Kazumi Kitta et al.
The Journal of biological chemistry, 278(7), 4705-4712 (2002-12-07)
Hepatocyte growth factor (HGF) is released in response to myocardial infarction and may play a role in regulating cardiac remodeling. Recently, HGF was found to inhibit the apoptosis of cardiac muscle cells. Because GATA-4 can induce cell survival, the effects

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