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H4881

Sigma-Aldrich

Hydrocortisone 21-hemisuccinate sodium salt

≥90% (HPLC)

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Synonym(s):
11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate sodium salt, Cortisol 21-hemisuccinate sodium salt
Empirical Formula (Hill Notation):
C25H33NaO8
CAS Number:
Molecular Weight:
484.51
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

assay

≥90% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(COC(CCC([O-])=O)=O)=O)=C1.[Na+]

InChI

1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1

InChI key

HHZQLQREDATOBM-CODXZCKSSA-M

Gene Information

human ... NR3C1(2908)

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This Item
P4153M3781P9521
21-Deoxycortisol

P9521

21-Deoxycortisol

form

powder

form

powder

form

lyophilized powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

room temp

storage temp.

room temp

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

water: 50 mg/mL, clear, colorless

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

ethanol: 9.80-10.20 mg/mL, clear, colorless

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

Application

Hydrocortisone 21-hemisuccinate sodium salt has been used:
  • as a component of the maturation medium for hepatic differentiation
  • in the corticosterone (CORT) treatment to study its effect on astrocyte-like neural stem cell proliferation in the area postrema of the adult mouse brain
  • in cortisol incubation experiments to study the effect of cortisol on the expression and function of sodium-chloride cotransporter (NCC) in zebrafish embryos

pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Influence Of Cortisol On The Attachment And Metamorphosis Of Larval Utterbackia Imbecillis On Bluegill Sunfish (Lepomis Macrochirus).
Dubansky, B., et al.
The Biochemical Journal, 220, 97-106 (2011)
Yuri Nambu et al.
Neuroscience letters, 748, 135732-135732 (2021-02-17)
The discovery of neural stem cells (NSCs) in the adult mammalian brain has provided insights into an extra level of brain plasticity. The proliferation and differentiation of NSCs is modulated by various physiological, pathological, and pharmacological stimuli. NSCs were recently
Yuri Nambu et al.
Neuroscience letters, 748, 135732-135732 (2021-02-17)
The discovery of neural stem cells (NSCs) in the adult mammalian brain has provided insights into an extra level of brain plasticity. The proliferation and differentiation of NSCs is modulated by various physiological, pathological, and pharmacological stimuli. NSCs were recently
Chia-Hao Lin et al.
Molecular and cellular endocrinology, 422, 93-102 (2015-12-19)
In mammals, sodium/hydrogen exchanger (NHE) and sodium-chloride cotransporter (NCC) are expressed in renal tubules, and exhibit functional redundancy and mutual compensation in Na(+) uptake. In teleosts, the gills of the adult and skin of the embryonic stage function as external
Y Baert et al.
Human reproduction (Oxford, England), 35(5), 1029-1044 (2020-05-12)
Is it possible to co-culture and functionally link human liver and testis equivalents in the combined medium circuit of a multi-organ chip? Multi-organ-chip co-cultures of human liver and testis equivalents were maintained at a steady-state for at least 1 week and

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