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H5257

Sigma-Aldrich

Hispidin

solid, ≥98% (HPLC)

Synonym(s):

6-(3,4-dihydroxystyrl)-4-hydroxy-2-pyrone

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About This Item

Empirical Formula (Hill Notation):
C13H10O5
CAS Number:
555-55-5
Molecular Weight:
246.22
MDL number:
MFCD01866972
UNSPSC Code:
12352200
PubChem Substance ID:
24278468
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

yellow to brown

mp

237.5-238.5  °C

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

SMILES string

OC1=CC(/C=C/C(O2)=CC(O)=CC2=O)=CC=C1O

InChI

1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+

InChI key

SGJNQVTUYXCBKH-HNQUOIGGSA-N

Gene Information

human ... PRKACB(5567) , PRKAR2B(5577) , PRKCB(5579)

General description

Hispidin is a phenolic compound, that is obtained from a medicinal mushroom, Phellinus linteus.

Biochem/physiol Actions

Hispidin exhibits robust antioxidant, anticancer and antidiabetic properties. It has the ability to guard against peroxynitrite-mediated cytotoxicity, DNA damage and the development of hydroxyl radicals.
Potent inhibitor of protein kinase Cβ, cytotoxic for cancer cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

No data available

flash_point_c

No data available

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000333775
0000337039
0000333775
0000284218
0000174954

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Alvaro Macias et al.
International journal of molecular sciences, 22(3) (2021-02-13)
KV1.5 channel function is modified by different regulatory subunits. KVβ1.3 subunits assemble with KV1.5 channels and induce a fast and incomplete inactivation. Inhibition of PKC abolishes the KVβ1.3-induced fast inactivation, decreases the amplitude of the current KV1.5-KVβ1.3 and modifies their
Prabodh Risal et al.
Journal of natural products, 75(10), 1683-1689 (2012-10-03)
In this study the protective effects of davallialactone (1), isolated from Inonotus xeranticus, have been examined against carbon tetrachloride (CCl₄-induced acute liver injury. Mice received subcutaneous injection of 1 (2.5, 5, and 10 mg/kg) for three days before CCl₄ injection
Sirosh M Bokhari et al.
The Journal of investigative dermatology, 126(2), 460-467 (2005-12-24)
Activation of protein kinase C (PKC) induces phenotypic changes in the morphology of microvascular endothelial cells that affect major functions of the microvasculature. These functions include the first stages of sprouting in angiogenesis, cell migration following wounding, and vascular permeability.
Jinxi Huo et al.
Journal of advanced research, 24, 325-335 (2020-05-27)
Phellinus gilvus (Schwein.) Pat, a species of 'Sanghuang', has been well-documented for various medicinal uses, but the genome information and active constituents are largely unknown. Here, we sequenced the whole-genome of P. gilvus, identified phenylpropanoids as its key anti-cancer components
Craig Slattery et al.
The international journal of biochemistry & cell biology, 40(10), 2218-2229 (2008-04-29)
Cyclosporine A (CsA) significantly improves the success of organ transplantation, however renal fibrosis, characterised by severe tubulointerstitial fibrosis is a complication of CsA therapy. Previously we have reported the involvement of PKC-beta isoforms in a model of CsA-induced tubulointerstitial fibrosis
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