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I2764

Sigma-Aldrich

ML-7

powder

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Synonym(s):
1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride
Empirical Formula (Hill Notation):
C15H17IN2O2S · HCl
CAS Number:
Molecular Weight:
452.74
MDL number:
PubChem Substance ID:
NACRES:
NA.77

assay

≥98% (TLC)

Quality Level

form

powder

color

white

solubility

ethanol: water (1:1): 10 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cl.Ic1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3

InChI

1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H

InChI key

KDDALCDYHZIZMH-UHFFFAOYSA-N

Gene Information

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This Item
I6891SML0633475880
ML-7 powder

I2764

ML-7

H-7

I6891

H-7

Sigma-Aldrich

SML0633

UNC0646

ML-7, Hydrochloride A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM).

475880

ML-7, Hydrochloride

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

>98% (TLC)

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

ethanol: water (1:1): 10 mg/mL, clear, colorless to faintly yellow

solubility

ethanol: 20 mg/mL, 1 M HCl: 5 mg/mL

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

50% ethanol: 4.5 mg/mL, DMSO: 4.5 mg/mL

color

white

color

-

color

white to beige

color

white

Application

ML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.

Biochem/physiol Actions

Selective myosin light chain kinase inhibitor.

Features and Benefits

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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M Makishima et al.
FEBS letters, 287(1-2), 175-177 (1991-08-05)
Inhibitors of myosin light chain kinase, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-9) and 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), induced Nitroblue tetrazolium reducing activity, lysozyme activity and morphological maturation of human monoblastic U937, THP-1 and promyelocytic HL-60 cells, but not of erythroblastic K562 cells. However, three
Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection
Antoine TE and Shukla D
Antiviral Therapy, 19, 15-29 (2014)
Kristopher E Kubow et al.
Scientific reports, 7(1), 14380-14380 (2017-11-01)
Contact guidance-cell polarization by anisotropic substrate features-is integral to numerous physiological processes; however the complexities of its regulation are only beginning to be discovered. In particular, cells polarize to anisotropic features under non-muscle myosin II (MII) inhibition, despite MII ordinarily
Zasp/Cypher internal ZM-motif containing fragments are sufficient to co-localize with alpha-actinin?Analysis of patient mutations
Klaavuniemi T and Ylanne J
Experimental Cell Research, 312(8), 1299-1311 (2006)
Sylvain Recoquillon et al.
Scientific reports, 7(1), 13664-13664 (2017-10-24)
Obstructive sleep apnea is characterized by intermittent hypoxia (IH) which alters endothelial function, induces inflammation and accelerates atherosclerosis-induced cardiovascular diseases. The non-muscular myosin light chain kinase (nmMLCK) isoform contributes to endothelial cell-cell junction opening. Deletion of nmMLCK protects mice from

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