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I5152

Sigma-Aldrich

Anti-Interferon-γ Receptor 1 (IFN-γ R1) antibody produced in goat

affinity isolated antibody, lyophilized powder

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Synonym(s):
Anti-CD119, Anti-IFNGR, Anti-IMD27A, Anti-IMD27B
MDL number:

biological source

goat

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

immunocytochemistry: 5-15 μg/mL using immersion fixed human peripheral blood mononuclear cells
neutralization: suitable
western blot: 0.1 μg/mL

isotype

IgG

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IFNGR1(3459)

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This Item
I5521SAB4501514HPA063871
biological source

goat

biological source

mouse

biological source

rabbit

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

clone

polyclonal

clone

25718, monoclonal

clone

polyclonal

clone

polyclonal

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

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General description

Human Interferon-γ- Receptor I (IFN-γ RI) is a 25kD, 227 amino acid residue containing protein that belongs to type II cytokine receptor family. IFN-γ RI has a crucial role in ligand-binding and signaling. Ligand IFN-γ induces tyrosine phosphorylation in IFN-γ RI which in turn leads to the formation of a docking site on the activated receptor for Stat1 that specifically activates IFN-γ induced gene transcription. Anti-Interferon γ Receptor I (IFN-γ RI) antibody can be used in neutralization assay using a confluent culture of HeLa cells. Goat anti-Interferon γ Receptor I (IFN-γ RI) antibody reacts specifically with recombinant human IFN-γ RI. The product has shown no cross-reactivity for recombinant human IFN-γ RII.

Immunogen

recombinant human IFN-γ Receptor I extracellular domain expressed in NSO cells.

Application

Anti-Interferon γ Receptor I (IFN-γ RI) antibody can be used in indirect ELISA and western blot.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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O Silvennoinen et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 105(7), 497-509 (1997-07-01)
Cytokines are the principal regulators of cell proliferation and differentiation of hematopoietic cells and these responses are initiated through activation of hematopoietic cytokine receptors. Although the receptor intracellular domains lack any kinase domains, activation of cytokine receptors lead to rapid
E A Bach et al.
Annual review of immunology, 15, 563-591 (1997-01-01)
During the last several years, the mechanism of IFN gamma-dependent signal transduction has been the focus of intense investigation. This research has recently culminated in the elucidation of a comprehensive molecular understanding of the events that underlie IFN gamma-induced cellular
A C Greenlund et al.
The EMBO journal, 13(7), 1591-1600 (1994-04-01)
Herein we report that interferon-gamma (IFN gamma) induces the rapid and reversible tyrosine phosphorylation of the IFN gamma receptor. Using a panel of receptor intracellular domain mutants, we show that a membrane-proximal LPKS sequence (residues 266-269) is required for ligand-induced

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