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L2540

Sigma-Aldrich

L-368,899

≥98% (HPLC), powder

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Synonym(s):
1-((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo[2,2,1]heptan-1(S)-yl)methylsulfonyl)-4-(2-methylphenyl)piperazine hydrochloride
Empirical Formula (Hill Notation):
C26H42O5N4S2 · HCl
Molecular Weight:
591.23
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white

solubility

H2O: soluble 20 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

−20°C

SMILES string

Cl.Cc1ccccc1N2CCN(CC2)S(=O)(=O)C[C@]34CC[C@H](C[C@@H]3NC(=O)[C@@H](N)CCS(C)(=O)=O)C4(C)C

InChI

1S/C26H42N4O5S2.ClH/c1-19-7-5-6-8-22(19)29-12-14-30(15-13-29)37(34,35)18-26-11-9-20(25(26,2)3)17-23(26)28-24(31)21(27)10-16-36(4,32)33;/h5-8,20-21,23H,9-18,27H2,1-4H3,(H,28,31);1H/t20-,21+,23+,26-;/m1./s1

InChI key

GIUFQWFJHXXXEQ-SWJTYIIKSA-N

Gene Information

human ... OXTR(5021)

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L-368,899 ≥98% (HPLC), powder

Sigma-Aldrich

L2540

L-368,899

GSK2801 ≥98% (HPLC)

Sigma-Aldrich

SML0768

GSK2801

MC2050 hydrate ≥98% (HPLC)

Sigma-Aldrich

SML0213

MC2050 hydrate

MLS000389544 ≥98% (HPLC)

Sigma-Aldrich

SML0290

MLS000389544

form

powder

form

powder

form

powder

form

powder

color

white

color

, white to pink to light brown

color

white to beige

color

white to beige

solubility

H2O: soluble 20 mg/mL

solubility

DMSO: 10 mg/mL, clear

solubility

H2O: ≥5 mg/mL at warmed to 60 °C

solubility

H2O: ≥5 mg/mL (warmed)

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

originator

-

originator

-

originator

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

Biochem/physiol Actions

L-368,899 is a non-peptide oxytocin receptor (OTR) antagonist.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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25G
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Marianna Leonzino et al.
Hormones and behavior, 114, 104543-104543 (2019-06-21)
Long-standing studies established a role for the oxytocin system in social behavior, social reward, pair bonding and affiliation. Oxytocin receptors, implicated in pathological conditions affecting the social sphere such as autism spectrum disorders, can also modulate cognitive processes, an aspect
Ling Huang et al.
Brain research bulletin, 166, 161-171 (2020-12-07)
Social experiences during early life are thought to be critical for proper social and emotional development. Conversely, social insults during development causes long-lasting behavioral abnormalities later in life. However, how juvenile social deprivation influences social and emotional behaviors remains poorly

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