Skip to Content
MilliporeSigma
All Photos(2)

Key Documents

View All Documentation

M3281

Sigma-Aldrich

α-Methyl-DL-tyrosine methyl ester hydrochloride

≥95% (HPLC)

Synonym(s):

α-MT methyl ester hydrochloride, 2-Methyl-4-hydroxy-DL-phenylalanine methyl ester hydrochloride, AMPT methyl ester hydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Linear Formula:
4-(HO)C6H4CH2C(CH3)(NH2)CO2CH3 · HCl
CAS Number:
7361-31-1
Molecular Weight:
245.70
Beilstein/REAXYS Number:
5163031
EC Number:
230-900-0
MDL number:
MFCD00012606
UNSPSC Code:
12352108
PubChem Substance ID:
24278548
NACRES:
NA.32

Quality Level

100

assay

≥95% (HPLC)

mp

192 °C (dec.) (lit.)

solubility

DMSO: ≥20 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cl[H].COC(=O)C(C)(N)Cc1ccc(O)cc1

InChI

1S/C11H15NO3.ClH/c1-11(12,10(14)15-2)7-8-3-5-9(13)6-4-8;/h3-6,13H,7,12H2,1-2H3;1H

InChI key

OOVDEPZODSXAMU-UHFFFAOYSA-N

Gene Information

human ... TH(7054)

Looking for similar products? Visit Product Comparison Guide

Application

α-Methyl-DL-tyrosine methyl ester hydrochloride has been used to evaluate norepinephrine turnover.

Biochem/physiol Actions

α-Methyl-DL-tyrosine (α-MT) prevents hyperactivity, sniffing-licking-gnawing syndrome, anorexia and ameliorates certain effects of amphetamine. It inhibits dopamine production and prevents apoptosis stimulated by mutant α-synuclein.
Tyrosine hydroxylase inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCW4500
MKCG6361
MKCH4453
MKCF1698
MKCC3199

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 2

1 of 2

3-Iodo-L-tyrosine

Sigma-Aldrich

I8250

3-Iodo-L-tyrosine

Reserpine

Sigma-Aldrich

R0875

Reserpine

Central sympathetic innervations to visceral and subcutaneous white adipose tissue
Nguyen, Ngoc Ly T and Randall, Jessica and Banfield, Bruce W and Bartness, Timoth NLT, et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 306(6), R375-R386 (2014)
Antiamphetamine effects following inhibition of tyrosine hydroxylase
Weissman A
Journal of Pharmacology and Experimental Therapeutics, 151(3), 339-352 (1966)
Y Maruyama et al.
Arzneimittel-Forschung, 41(10), 1022-1026 (1991-10-01)
The present study was undertaken to elucidate beta-adrenoceptor blocking effects of befunolol (BFE 60, CAS 39543-79-8) on changes in the myocardial metabolites induced by hypoxic respiration. When rats were subjected to hypoxic respiration, a significant increase in heart rate (about
E Sundström et al.
Brain research, 528(2), 181-188 (1990-10-01)
The long-term effect of the parkinsonism inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on pre- and postsynaptic structures of the nigrostriatal and mesolimbic dopamine (DA) system in adult C57BL/6 mice (2 x 40 mg/kg s.c.) was investigated using neurochemical and behavioral methods. It
J J Liaw et al.
Brain research. Molecular brain research, 13(3), 231-238 (1992-04-01)
Temporal changes in tyrosine hydroxylase (TH) mRNA levels in medullary A1 and A2 neurons and locus coeruleus (LC) cells were studied 6, 12 and 24 h following orchidectomy in rats. Brains from intact controls and sham castrated rats also were
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service