M7945

Mephetyl tetrazole

≥98% (HPLC), oil

• Synonym(s): 1-[2-(4-Methoxyphenyl)ethyl]-5-(1-p-tolylcyclopropyl)-1H-tetrazole
• Empirical Formula (Hill Notation): C₂₀H₂₂N₄O
• CAS Number: 916923-10-9
• Molecular Weight: 334.41
• MDL number: MFCD11045297
• UNSPSC Code: 12352200
• PubChem Substance ID: 329818044
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: oil
• color: pale yellow
• solubility: DMSO: >5 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1ccc(CCn2nnnc2C3(CC3)c4ccc(C)cc4)cc1
• InChI: 1S/C20H22N4O/c1-15-3-7-17(8-4-15)20(12-13-20)19-21-22-23-24(19)14-11-16-5-9-18(25-2)10-6-16/h3-10H,11-14H2,1-2H3
• InChI key: VREPWWBWXVLSEF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC₅₀ = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)