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Monoclonal Anti-Myelin Basic Protein (MBP) (36-50) antibody produced in rat

clone 14, tissue culture supernatant

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MDL number:

biological source


Quality Level



antibody form

tissue culture supernatant

antibody product type

primary antibodies


14, monoclonal


0.09% sodium azide

species reactivity

horse, chicken, human


ELISA: suitable
immunofluorescence: suitable
immunohistochemistry: suitable



UniProt accession no.

shipped in

dry ice

storage temp.


target post-translational modification


Gene Information

human ... MBP(4155)

General description

Myelin basic protein (MBP) is part of the myelin sheath and is a calcium-dependent protein. It has six isoforms and the gene encoding it is localized on human chromosome 18q23.


Recognizes amino acids 36-50 of myelin basic protein.


bovine myelin basic protein.

Biochem/physiol Actions

Myelin basic protein (MBP) associates with calmodulin and has been identified as an auto-antigen in multiple sclerosis (MS). It also inhibits the assembly of amyloid-β protein.

Preparation Note

Generated by somatic cell hybridization of NS0 myeloma cells with spleen cells from an outbred rat immunized with bovine myelin basic protein.


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Storage Class

10 - Combustible liquids

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Anti-MBP affinity isolated antibody




Alexey Belogurov et al.
The Journal of biological chemistry, 289(25), 17758-17766 (2014-04-18)
The vast majority of cellular proteins are degraded by the 26S proteasome after their ubiquitination. Here, we report that the major component of the myelin multilayered membrane sheath, myelin basic protein (MBP), is hydrolyzed by the 26S proteasome in a
Neha Soni et al.
Frontiers in neurology, 11, 153-153 (2020-03-27)
Early loss of white matter microstructure integrity is a significant cause of long-term neurological disorders following traumatic brain injury (TBI). White matter abnormalities typically involve axonal loss and demyelination. In-vivo imaging tools to detect and differentiate such microstructural changes are
H K Palliser et al.
Neuroendocrinology, 96(1), 60-67 (2012-04-18)
Intra-uterine growth restriction (IUGR) is a significant in utero complication that can have profound effects on brain development including reduced myelination and deficits that can continue into adulthood. Progesterone increases oligodendrocyte proliferation and myelin expression, an action that may depend
Frank Rattay et al.
PloS one, 8(11), e79256-e79256 (2013-11-22)
Our knowledge about the neural code in the auditory nerve is based to a large extent on experiments on cats. Several anatomical differences between auditory neurons in human and cat are expected to lead to functional differences in speed and
Ekaterina Kuzina et al.
BioMed research international, 2014, 926394-926394 (2014-10-03)
We recently showed that myelin basic protein (MBP) is hydrolyzed by 26S proteasome without ubiquitination. The previously suggested concept of charge-mediated interaction between MBP and the proteasome led us to attempt to compensate or mimic its positive charge to inhibit

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