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Novobiocin sodium salt

≥90% (HPLC)

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Albamycin, Albamycin Sodium, Cathomycin sodium
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
PubChem Substance ID:

biological source


Quality Level


≥90% (HPLC)



storage condition

(Tightly closed. Dry. )


white to yellow

antibiotic activity spectrum

Gram-positive bacteria

mode of action

DNA synthesis | interferes
enzyme | inhibits

storage temp.


SMILES string




InChI key


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General description

Novobiocin sodium salt is an antibiotic derived from soil bacteria. Novobiocin inhibits the action of bacterial DNA gyrase and belongs to a class of compounds called coumarin antibiotics. Coumarins are heterocyclic compounds with a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumor, and enzyme inhibitory effects.


Novobiocin Sodium Salt, an inhibitor of Hsp90, can be used:
  • in the research heat shock protein inhibition and to produce positively supercoiled plasmid DNA
  • in the research on the efficacy of probiotics
  • in the research on the efficacy of human monocytes and dendritic cells for T-cell replication
For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.

Biochem/physiol Actions

Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.
Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.

Features and Benefits

High quality antibiotic suitable for mulitple research applications

Storage and Stability

Stored in frozen aliquots, Keep container tightly closed in a dry and well-ventilated place. Light sensitive

Other Notes

For additional information on our range of Biochemicals, please complete this form.

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Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids




Not applicable


Not applicable


dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Temporal effects of lactic acid bacteria probiotic culture on Salmonella in neonatal broilers
Higgins et al.
Poultry Science, Aug;86(8):, 1662-1666 (2007)
A Maxwell
Molecular microbiology, 9(4), 681-686 (1993-08-01)
The coumarin group of antibiotics have as their target the bacterial enzyme DNA gyrase. The drugs bind to the B subunit of gyrase and inhibit DNA supercoiling by blocking the ATPase activity. Recent data show that the binding site for
Evaluation of a Lactobacillus-based probiotic culture for the reduction of Salmonella enteritidis in neonatal broiler chicks
Higgins et al.
Poultry Science, 87, 27-31 (2008)
Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication
Voorhis et al.
The Journal of Experimental Medicine, 58, 174-191 (1983)
Yosef D Huberman et al.
Poultry science, 98(6), 2422-2431 (2019-01-29)
Salmonellosis caused by Salmonella Enteritidis is a widespread zoonosis and poultry products are an important source of infection. This study was carried out to evaluate the protection of different vaccination schedules in layers using a live commercial attenuated Salmonella Enteritidis

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