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N1628

Sigma-Aldrich

Novobiocin sodium salt

≥90% (HPLC)

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Synonym(s):
Albamycin, Albamycin Sodium, Cathomycin sodium
Empirical Formula (Hill Notation):
C31H35N2NaO11
CAS Number:
Molecular Weight:
634.61
Beilstein/REAXYS Number:
3892910
EC Number:
PubChem Substance ID:
NACRES:
NA.85

biological source

(STREPTOMYCES NIVEUS)

Quality Level

assay

≥90% (HPLC)

form

powder

storage condition

(Tightly closed. Dry. )

color

white to yellow

antibiotic activity spectrum

Gram-positive bacteria

mode of action

DNA synthesis | interferes
enzyme | inhibits

storage temp.

2-8°C

SMILES string

[Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C

InChI

1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1

InChI key

AXOUUAINTJNFRS-UHFFFAOYSA-N

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General description

Novobiocin sodium salt is an antibiotic derived from soil bacteria. Novobiocin inhibits the action of bacterial DNA gyrase and belongs to a class of compounds called coumarin antibiotics. Coumarins are heterocyclic compounds with a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumor, and enzyme inhibitory effects.

Application

Novobiocin Sodium Salt, an inhibitor of Hsp90, can be used:
  • in the research heat shock protein inhibition and to produce positively supercoiled plasmid DNA
  • in the research on the efficacy of probiotics
  • in the research on the efficacy of human monocytes and dendritic cells for T-cell replication
For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.

Biochem/physiol Actions

Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.
Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.

Features and Benefits

High quality antibiotic suitable for mulitple research applications

Storage and Stability

Stored in frozen aliquots, Keep container tightly closed in a dry and well-ventilated place. Light sensitive

Other Notes

For additional information on our range of Biochemicals, please complete this form.

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Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Temporal effects of lactic acid bacteria probiotic culture on Salmonella in neonatal broilers
Higgins et al.
Poultry Science, Aug;86(8):, 1662-1666 (2007)
A Maxwell
Molecular microbiology, 9(4), 681-686 (1993-08-01)
The coumarin group of antibiotics have as their target the bacterial enzyme DNA gyrase. The drugs bind to the B subunit of gyrase and inhibit DNA supercoiling by blocking the ATPase activity. Recent data show that the binding site for
Evaluation of a Lactobacillus-based probiotic culture for the reduction of Salmonella enteritidis in neonatal broiler chicks
Higgins et al.
Poultry Science, 87, 27-31 (2008)
Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication
Voorhis et al.
The Journal of Experimental Medicine, 58, 174-191 (1983)
Yosef D Huberman et al.
Poultry science, 98(6), 2422-2431 (2019-01-29)
Salmonellosis caused by Salmonella Enteritidis is a widespread zoonosis and poultry products are an important source of infection. This study was carried out to evaluate the protection of different vaccination schedules in layers using a live commercial attenuated Salmonella Enteritidis

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