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N3877

Sigma-Aldrich

Potassium 4-nitrophenyl sulfate

sulfatase substrate, chromogenic, ≥98% (TLC), powder

Synonym(s):

4-Nitrophenyl sulfate potassium salt

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About This Item

Linear Formula:
NO2C6H4OSO2OK
CAS Number:
6217-68-1
Molecular Weight:
257.26
Beilstein/REAXYS Number:
3786392
EC Number:
228-288-5
MDL number:
MFCD00007466
UNSPSC Code:
12352204
PubChem Substance ID:
24897664
NACRES:
NA.32

Product Name

Potassium 4-nitrophenyl sulfate, sulfatase substrate

assay

≥98% (TLC)

form

powder

mp

246-250 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless to very faintly greenish-yellow (to Very Light Yellow)

shipped in

wet ice

storage temp.

−20°C

SMILES string

[K+].[O-][N+](=O)c1ccc(OS([O-])(=O)=O)cc1

InChI

1S/C6H5NO6S.K/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12;/h1-4H,(H,10,11,12);/q;+1/p-1

InChI key

BITVAZYUWRLLCN-UHFFFAOYSA-M

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Application

Potassium 4-nitrophenyl sulfate has been used:
  • as a substrate to measure arylsulfatase activity in cell-free coelomic fluid
  • as a substrate for p-nitrophenyl glycoside-based enzyme assay
  • to inhibit arylsulfatase
  • as an inorganic analog of organic aryl ester sulphate

Substrates

Chromogenic sulfatase substrate.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000427873
0000427872
0000427872
0000427873
0000427344

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M P Kung et al.
Endocrinology, 122(4), 1195-1200 (1988-04-01)
Subcellular preparations from rat liver, brain, and kidney and from human liver were tested for their ability to desulfate T3 sulfate (T3SO4). Activity was found associated with the microsomal fraction: rat liver was the most active, hydrolyzing 76 pmol/min.mg protein
H X Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 19(2), 473-477 (1991-03-01)
Although numerous previous reports have characterized the mammalian biotransformation of the organophosphorus insecticides parathion and methyl parathion, questions still remain regarding the toxicological significance of certain metabolic pathways in vivo. The present study utilized rat liver perfusions in order to
Proteomic profiles reveal age-related changes in coelomic fluid of sea urchin species with different life spans
Bodnar A
Experimental Gerontology, 48(5), 525-530 (2013)
An evaluation of wet chemical methods for quantifying sulfur fractions in freshwater wetland peat 1
Wieder RK, et al.
Limnology and Oceanography, 30(5), 1109-1115 (1985)
Shina Caroline Lynn Kamerlin
The Journal of organic chemistry, 76(22), 9228-9238 (2011-10-11)
Both phosphoryl and sulfuryl transfers are ubiquitous in biology, being involved in a wide range of processes, ranging from cell division to apoptosis. Additionally, it is becoming increasingly clear that enzymes that can catalyze phosphoryl transfer can often cross-catalyze sulfuryl
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