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P0781

Sigma-Aldrich

Penicillin-Streptomycin

with 10,000 units penicillin and 10 mg streptomycin per mL in 0.9% NaCl, 0.1 μm filtered, BioReagent, suitable for cell culture

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Synonym(s):
Pen-Strep
PubChem Substance ID:
NACRES:
NA.76

Quality Level

sterility

0.1 μm filtered

product line

BioReagent

form

liquid

concentration

100 ×

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

cell wall synthesis | interferes
protein synthesis | interferes

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(O)=O.CNC[C@H]4[C@H](O)[C@@H](O)[C@H](CCO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)C5(O)C=O)O[C@H]6[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]6NC(N)=N

InChI

1S/C23H43N7O12.C16H18N2O4S/c1-7-23(38,6-32)18(42-19-8(5-28-2)12(33)13(34)9(40-19)3-4-31)20(39-7)41-17-11(30-22(26)27)14(35)10(29-21(24)25)15(36)16(17)37;1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h6-20,28,31,33-38H,3-5H2,1-2H3,(H4,24,25,29)(H4,26,27,30);3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t7-,8-,9-,10+,11-,12-,13-,14+,15-,16+,17+,18-,19-,20-,23+;11-,12+,14-/m01/s1

InChI key

KMOOCZWLFBSQCW-XFOLRDBHSA-N

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This Item
P4458P7539G6784
product line

BioReagent

product line

BioReagent

product line

BioReagent

product line

BioReagent

form

liquid

form

liquid

form

liquid

form

liquid

concentration

100 ×

concentration

50 ×

concentration

-

concentration

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | hybridoma: suitable

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

impurities

endotoxin, tested

impurities

endotoxin, tested

impurities

endotoxin, tested

General description

Penicillin streptomycin, also known as Pen-Strep, is the most commonly used antibiotic solution for culture of mammalian cells. Penicillin Streptomycin solution is used to maintain sterile conditions during cell culture, and they show few adverse effects on the cultured cells.

Application

Penicillin-Streptomycin solution is used to supplement cell culture media to control bacterial contamination. It has also been used for the preparation of lipid emulsions. It is recommended for use in cell culture applications at 10 mL/L.

Components

This product is formulated to contain 10,000 units penicillin and 10 mg streptomycin/mL.

Other Notes

20x100ml,20ml,100ml
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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184: Toxic effects of antibiotics routinely used in cell culture on primary cultures of dissociated mouse brain cells.
Amonn F
Pediatric Research, 10(10), 900-900 (1976)
D T Stein et al.
The Journal of clinical investigation, 100(2), 398-403 (1997-07-15)
Lowering of the elevated plasma FFA concentration in 18- 24-h fasted rats with nicotinic acid (NA) caused complete ablation of subsequent glucose-stimulated insulin secretion (GSIS). Although the effect of NA was reversed when the fasting level of total FFA was
Bryan Brown et al.
Tissue engineering, 12(3), 519-526 (2006-04-04)
The extracellular matrix (ECM) has been successfully used as a scaffold for constructive remodeling of multiple tissues in both preclinical studies and in human clinical applications. The basement membrane is a specialized form of the ECM that supports and facilitates
R M Pereira et al.
Animal reproduction science, 98(3-4), 293-301 (2006-04-29)
An excessive lipid content in embryo cells is a consequence of embryo culture in the presence of serum which is suggested to be responsible for their high susceptibility to cryopreservation. The objective of the present study was to examine the
Veerle Kersemans et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 49(9), 1546-1554 (2008-08-16)
Multidrug resistance (MDR) is a major challenge to the successful treatment of acute myeloid leukemia (AML). Our purpose was to determine whether (111)In-HuM195 anti-CD33 antibodies modified with peptides harboring nuclear localizing sequences (NLS) could kill drug-resistant AML cell lines and

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