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P1306

Sigma-Aldrich

Peptide YY human

≥97% (HPLC), synthetic

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Synonym(s):
PYY, Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2
Empirical Formula (Hill Notation):
C194H295N55O57
CAS Number:
Molecular Weight:
4309.75
MDL number:
NACRES:
NA.32

biological source

synthetic

Quality Level

assay

≥97% (HPLC)

form

solid

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... PYY(5697)

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P5801C9781G2269
vibrant-m

P1306

Peptide YY human

vibrant-m

P5801

Peptide YY porcine

vibrant-m

C9781

Tyr-C-Peptide human

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

solid

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... PYY(5697)

Gene Information

pig ... PYY(445018)

Gene Information

human ... INS(3630)

Gene Information

human ... GIP(2695)

Amino Acid Sequence

Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2

General description

Human peptide YY (PYY) is secreted by mucosal L cells in the distal ileum, colon and rectum. It consists of 36 amino acids. The gene encoding PYY is localized on human chromosome 17q21.1.

Application

Peptide YY human has been used as a supplement in Roswell Park Memorial Institute medium (RPMI medium) to culture pancreatic duct-derived cells.

Biochem/physiol Actions

Gut hormone that inhibits both secretin and cholecystokinin-stimulated pancreatic secretion. Endogenous nonselective agonist at NPY receptors.
Human peptide YY (PYY) has a role in food ingestion, gut motility and insulin secretion. The protein suppresses appetite. It has been associated with obesity and type 2 diabetes. PYY also has a role in energy homeostasis.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Expression of peptide YY by human blood leukocytes.
Holler JP
Peptides (2014)
Genomic and gene expression signature of the pre-invasive
testicular carcinoma in situ
Kristian Almstrup
Cell and Tissue Research (2005)
TLR ligands and butyrate increase Pyy expression through two distinct but inter-regulated pathways.
Larraufie P
Cellular Microbiology (2017)
Rapid and Efficient In Vitro Generation of Pancreatic Islet
Progenitor Cells from Nonendocrine Epithelial Cells in the
Adult Human Pancreas
JOSEPHINE S. D?ALESSANDRO
Stem Cells and Development (2007)
The Association of Serum Total Peptide YY (PYY) with Obesity and Body Fat Measures in the CODING Study.
Cahill F
PLoS ONE (2014)

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