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PRS2265

Sigma-Aldrich

Anti-Nephrin antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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Synonym(s):
CNF, NPHN, Renal glomerulus-specific cell adhesion receptor
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, human, mouse

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NPHS1(4868)

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This Item
ABT331SAB1402860SAB1305544
Anti-Nephrin Antibody from rabbit, purified by affinity chromatography

Sigma-Aldrich

ABT331

Anti-Nephrin Antibody

conjugate

unconjugated

conjugate

-

conjugate

unconjugated

conjugate

-

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

crude ascites

clone

polyclonal

clone

polyclonal

clone

3H6, monoclonal

clone

174CT2.1.1, monoclonal

form

buffered aqueous solution

form

-

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

rat, human, mouse

species reactivity

mouse

species reactivity

human

species reactivity

human

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General description

Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. It is a 1241-residue transmembrane protein. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomalrecessive disorder characterized by massive proteinuria in utero and nephrosis at birth. Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm.

Immunogen

Nephrin antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human
Nephrin. The immunogen is located within the last 50 amino acids of Nephrin.

Linkage

The action of this antibody can be blocked using blocking peptide SBP2265.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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