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PZ0374

Sigma-Aldrich

PF-06446846 hydrochloride

≥98% (HPLC)

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Synonym(s):
N-(3-Chloropyridin-2-yl)-N-((3R)-piperidin-3-yl)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
Empirical Formula (Hill Notation):
C22H20ClN7O · xHCl
CAS Number:
Molecular Weight:
433.89 (free base basis)
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -60 to -50°, c = 1 in methanol

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

room temp

SMILES string

O=C(C1=CC=C(N2C(N=CC=C3)=C3N=N2)C=C1)N([C@H]4CNCCC4)C5=C(Cl)C=CC=N5

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vibrant-m

PZ0374

PF-06446846 hydrochloride

vibrant-m

PZ0386

PF-06456384 trihydrochloride

vibrant-m

PZ0362

CP-640186 hydrochloride

vibrant-m

PZ0300

PF-06764427

form

powder

form

powder

form

powder

form

powder

solubility

H2O: 2 mg/mL, clear

solubility

H2O: 2 mg/mL, clear

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

-

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

Biochem/physiol Actions

PF-06446846 is a selective orally active PCSK9 inhibitor that appears to act by causing the ribosome to stall when synthesizing PCSK9. PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. PF-06446846 was found to reduce plasma PCSK9 and total cholesterol levels in rats.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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Nathanael G Lintner et al.
PLoS biology, 15(3), e2001882-e2001882 (2017-03-23)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in regulating the levels of plasma low-density lipoprotein cholesterol (LDL-C). Here, we demonstrate that the compound PF-06446846 inhibits translation of PCSK9 by inducing the ribosome to stall around codon 34

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