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S2644

Sigma-Aldrich

Anti-S-100 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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Synonym(s):
Anti-42C, Anti-ANX2LG, Anti-CAL1L, Anti-CLP11, Anti-Ca[1], Anti-GP11, Anti-P11, Anti-p10
MDL number:
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, bovine, guinea pig, human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 20-100 μg/mL using sections of human or rat cerebellum
microarray: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

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This Item
S2532S9684SAB1409624
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody form

ascites fluid

antibody form

IgG fraction of antiserum

antibody form

purified immunoglobulin

clone

polyclonal

clone

SH-B1, monoclonal

clone

polyclonal

clone

polyclonal

form

buffered aqueous solution

form

-

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

rat, bovine, guinea pig, human

species reactivity

feline, pig, bovine, sheep, goat, rabbit, canine, human, rat

species reactivity

rat, mouse

species reactivity

human

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General description

S-100 (S100 calcium binding protein A10) belongs to the EF-hand-containing S100 protein family. It is also termed as calpactin light chain, p11 or annexin 2 light chain. This gene is located on human chromosome 1q21.
S100 calcium binding protein A10 (S-100) is located on rat chromosome 2q34. It is also termed as p11.
The S-100 protein family consists of around 16 calcium binding proteins that have distinct tissue specific expression patterns. S-100 proteins are widely expressed in neural and non-neural cell types, as well as in several cancers. These proteins regulate a broad range of cellular functions such as cell growth, signaling, cell structure, and energy metabolism . In immunohistology, the product specifically stains the S-100 protein. The product binds to S-100 protein in human, rat, guinea pig, and bovine. In the brain, the antibody can be used to stain glial and ependymal cells, as well as Schwann cells of the peripheral nervous system. In the skin, melanocytes and Langerhans cells can be stained by the antibody product. In lymph nodes, interdigitating reticulum cells are positively stained by anti-S-100 antibody. S-100 staining can be observed in almost all human benign and malignant melanocytic tumors.

Immunogen

S-100 from bovine brain

Application

Anti-S-100 antibody has been used in immunocytochemistry,[25} immunofluorescence and immunostaining.
Anti-S-100 antibody is suitable for use in microarray, and immunohistochemistry (in formalin-fixed, paraffin-embedded sections, or using a conc. of 20-100 μg/mL in sections of human or rat cerebellum). The antibody may also be used in immunoelectrophoresis.

Biochem/physiol Actions

S-100 (S100 calcium binding protein A10) is required for trafficking of TRPV5 and TRPV6 (epithelial Ca2+ channels). S100A10 along with annexin 2, participates in several biological processes such as endocytosis, exocytosis and membrane-cytoskeleton interactions. It controls plasma membrane ion channels and cytosolic phospholipase A2.
S100 calcium binding protein A10 (S-100) plays an important role in depression-like character in rodents. In rat ventricular cardiomyocytes, p11 regulates calcium handling through 5-HT4R pathway.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Cells of primarily extravalvular origin in degenerative aortic valves and bioprostheses
Skowasch D, et al.
European Heart Journal, 26 (2005)
Functional expression of the epithelial Ca2+ channels (TRPV5 and TRPV6) requires association of the S100A10?annexin 2 complex.
van de Graaf SFJ, et al.
The Embo Journal, 22(7), 1478-1487 (2003)
Differences in the presence of mechanoreceptors and nerve structures between wrist ligaments may imply differential roles in wrist stabilization.
Hagert E, et al.
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 23(4), 757-763 (2005)
Katherine M Musick et al.
Scientific reports, 5, 14363-14363 (2015-09-25)
Reliably interfacing a nerve with an electrode array is one of the approaches to restore motor and sensory functions after an injury to the peripheral nerve. Accomplishing this with current technologies is challenging as the electrode-neuron interface often degrades over
Study of expression patterns and levels of neurotrophins and neurotrophin receptors in ulcerative colitis
Johansson M, et al.
Inflammatory bowel diseases, 13(4), 398-409 (2007)

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