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S3007

Sigma-Aldrich

Sodium salicylate

ReagentPlus®, ≥99.5% (titration)

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Synonym(s):
2-Hydroxybenzoic acid sodium salt, Salicylic acid sodium salt, Sodium 2-hydroxybenzoate
Linear Formula:
HOC6H4COONa
CAS Number:
Molecular Weight:
160.10
Beilstein/REAXYS Number:
3732792
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Quality Level

product line

ReagentPlus®

assay

≥99.5% (titration)

form

crystalline

color

white

useful pH range

6.85 (26.3 °C)

mp

>300 °C (lit.)

solubility

water: 575.7 g/L at 25 °C (77 °F)

SMILES string

[Na+].Oc1ccccc1C([O-])=O

InChI

1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1

InChI key

ABBQHOQBGMUPJH-UHFFFAOYSA-M

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This Item
1614636S0800000PHR3238
Sodium salicylate ReagentPlus®, ≥99.5% (titration)

S3007

Sodium salicylate

Sodium salicylate United States Pharmacopeia (USP) Reference Standard

1614636

Sodium salicylate

Sodium salicylate European Pharmacopoeia (EP) Reference Standard

S0800000

Sodium salicylate

Sodium Salicylate pharmaceutical secondary standard, certified reference material

PHR3238

Sodium Salicylate

assay

≥99.5% (titration)

assay

-

assay

-

assay

-

solubility

water: 575.7 g/L at 25 °C (77 °F)

solubility

-

solubility

-

solubility

-

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

>300 °C (lit.)

product line

ReagentPlus®

product line

-

product line

-

product line

-

color

white

color

-

color

-

color

-

General description

Sodium salicylate is the active ingredient in aspirin, commonly used as antipyretic, anti-inflammatory and analgesic drug. Sodium salicylate when taken in large quantities causes temporary hearing loss and tinnitus. Prolonged treatment with sodium salicylate reduces output from cochlea permanently, reduces compound action potential amplitude in vivo and neural degeneration in vitro. Sodium salicylate treatment in lateral amygdala alters tonography and excitability, causing hyperactivity in auditory cortex. Sodium salicylate impairs the expression of cellular-Finkel−Biskis−Jinkins murine osteogenic sarcoma virus (c-fos) and δ-FosB proteins in hippocampus region and affects spatial memory and learning. Sodium salicylate affects neurogenesis in dentate gyrus region of the brain.

Application

Sodium salicylate has been used:
  • to induce tinnitus, hyperacusis-like behavior in rats and infused directly into amygdala to measure local field potential.
  • to induce and confirm tinnitus by prepulse inhibition behavior (PPI) and its inhibition on learning and memory by Morris water maze test and subsequent gene expression studies in rats.
  • to enhance gamma amino butyric acid (GABA)ergic inhibition and enhance auditory response in the dorsal cortex of the inferior colliculus (ICd) measured by microiontophoretic technique.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation markHealth hazard

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

208.9 °F - Pensky-Martens closed cup

flash_point_c

98.3 °C - Pensky-Martens closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves


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