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S6201

Sigma-Aldrich

Salinomycin, Ready Made Solution

from Streptomyces albus, ≥98% (HPLC)

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Synonym(s):
Antibiotic 61477, Coxxistac
Empirical Formula (Hill Notation):
C42H70O11
Molecular Weight:
751.00
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

Streptomyces albus

Quality Level

assay

≥98% (HPLC)

concentration

2 mg/ml

solubility

DMSO: soluble
H2O: insoluble
alcohols: soluble
carbon tetrachloride: soluble
chloroform: soluble
ethers and esters: soluble
hexane: soluble

antibiotic activity spectrum

neoplastics

mode of action

cell membrane | interferes

shipped in

dry ice

storage temp.

−20°C

SMILES string

C[C@@H]1O[C@]([C@]2(C)CC[C@]3([C@H](O)C=C[C@]4(O[C@@]([C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)[C@@]5([H])[C@@H](C)CC[C@@]([C@H](C(O)=O)CC)([H])O5)=O)([H])[C@@H](C)C[C@H]4C)O3)O2)([H])CC[C@]1(O)CC

InChI

1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1

InChI key

KQXDHUJYNAXLNZ-XQSDOZFQSA-N

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Salinomycin, Ready Made Solution from Streptomyces albus, ≥98% (HPLC)

S6201

Salinomycin, Ready Made Solution

Salinomycin from Streptomyces albus, ≥98% (HPLC)

S4526

Salinomycin

Nigericin sodium salt ≥98% (TLC)

N7143

Nigericin sodium salt

Monensin sodium salt hydrate VETRANAL®, analytical standard

46468

Monensin sodium salt hydrate

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

200

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: soluble, alcohols: soluble, chloroform: soluble, hexane: soluble, H2O: insoluble, ethers and esters: soluble, carbon tetrachloride: soluble

solubility

-

solubility

-

solubility

-

shipped in

dry ice

shipped in

-

shipped in

-

shipped in

-

biological source

Streptomyces albus

biological source

Streptomyces albus

biological source

Streptomyces hygroscopicus

biological source

-

General description

Chemical structure: polyether

Application

Salinomycin, Ready Made Solution has been used as an inhibitor of endocytosis in primary pancreatic tumor cells. It has also been used in sequential treatment of cancer cells to study resistance.

Biochem/physiol Actions

Salinomycin is a monocarboxylic polyether antibiotic with unique tricyclic spiroketal ring systems and an unsaturated six-membered ring in the molecule. Salinomycin has antimicrobial and anticoccidial activities. It is an alkali ion carrier with affinity for cations and preference for K+ over other monovalent and divalent cations. Polyether antibiotics (also called carboxylic ionophores) facilitate bidirectional ion flux through the lipid barrier of membranes causing interference with natural ion transport systems both in prokaryotic and eukaryotic cells. Tumor cells express elevated levels of various types of K+ channels, which enhances cell proliferation. Thus, drugs acting as channel blockers inhibit cell proliferation. Being a highly selective potassium ionophore, salinomycin may interfere with potassium channels function in cancer stem cells (CSCs). Established cancer therapies may fail because they kill the bulk tumor cells, but do not eliminate CSCs. Studies indicate that Salinomycin selectively eradicates breast CSCs. Salinomycin may eliminate CSCs by inducing their differentiation. salinomycin suppresses the metastatic migration of 4T1 cells to the lungs.

Physical form

The product is supplied as a 2 mg/mL (2.66 mM) solution in DMSO, 0.2 μm-filtered.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup


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Brittney S Harrington et al.
Cancers, 12(6) (2020-06-25)
Disease recurrence is the major cause of morbidity and mortality of ovarian cancer (OC). In terms of maintenance therapies after platinum-based chemotherapy, PARP inhibitors significantly improve the overall survival of patients with BRCA mutations but is of little benefit to
Florian Kopp et al.
Translational oncology, 7(6), 702-711 (2014-12-17)
Acquiring therapy resistance is one of the major obstacles in the treatment of patients with cancer. The discovery of the cancer stem cell (CSC)-specific drug salinomycin raised hope for improved treatment options by targeting therapy-refractory CSCs and mesenchymal cancer cells.
Piyush B Gupta et al.
Cell, 138(4), 645-659 (2009-08-18)
Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell populations and their relative instability in culture. We describe here an approach to screening for
Qiao Ming Zhi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 65(7), 509-515 (2011-10-15)
Salinomycin is a novel identified cancer stem cells (CSCs) killer. Higher ALDH activity represents CSCs characterization. Here, we screened ALDH activities on several gastric cancer cell lines and divided them into ALDH(high) and ALDH(low) gastric cancer groups. ALDH(high) cancer cells
Hartmut Beug
Cell, 138(4), 623-625 (2009-08-26)
During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-throughput screen, which successfully identifies small molecules that

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