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S7951

Sigma-Aldrich

Ovalbumin (257-264) chicken

≥97% (HPLC), lyophilized powder, antigenic peptide 

Synonym(s):

L-seryl-L-isoleucyl-L-isoleucyl-L-asparaginyl-L-phenylalanyl-L-a-glutamyl-L-lysyl- L-Leucine trifluoroacetate, OVA (257 - 264), SIINFEKL trifluoroacetate salt, Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu trifluoroaceate, pOV8

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About This Item

Empirical Formula (Hill Notation):
C45H74N10O13 · xC2HF3O2
CAS Number:
138831-86-4
Molecular Weight:
963.13 (free base basis)
MDL number:
MFCD18452854
UNSPSC Code:
12352200
PubChem Substance ID:
329824593
NACRES:
NA.77

product name

Ovalbumin (257-264) chicken, ≥97% (HPLC)

Quality Level

200

assay

≥97% (HPLC)

form

lyophilized powder

color

white to off-white

solubility

H2O: >1 mg/mL

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O

InChI

1S/C45H74N10O13.C2HF3O2/c1-7-25(5)36(55-44(66)37(26(6)8-2)54-38(60)28(47)23-56)43(65)52-32(22-34(48)57)42(64)51-31(21-27-14-10-9-11-15-27)41(63)50-30(17-18-35(58)59)40(62)49-29(16-12-13-19-46)39(61)53-33(45(67)68)20-24(3)4;3-2(4,5)1(6)7/h9-11,14-15,24-26,28-33,36-37,56H,7-8,12-13,16-23,46-47H2,1-6H3,(H2,48,57)(H,49,62)(H,50,63)(H,51,64)(H,52,65)(H,53,61)(H,54,60)(H,55,66)(H,58,59)(H,67,68);(H,6,7)/t25-,26-,28-,29-,30-,31-,32-,33-,36-,37-;/m0./s1

InChI key

BRUCWCULSHVYBQ-VPZPQSBKSA-N

Amino Acid Sequence

Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu

Application

Ovalbumin (257-264) chicken has been used to trigger T cell activation in immunology studies.
Ovalbumin (257-264) chicken has been used:
  • to sensitize mice to generate an asthmatic model
  • in the stimulation of splenocytes
  • for treating dendritic cells to be used as a positive control in cross-presentation studies

Biochem/physiol Actions

Ovalbumin (257-264) chicken is an antigenic peptide and triggers immune response. Administration of the ovalbumin peptide in pregnant mice helps in surpassing ear development anomalies.
SIINFEKL is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA); the ovalbumin fragment is presented by the class I MHC molecule, H-2Kb.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Murine In vitro Memory T Cell Differentiation
Kim MV et al.
Bio-protocol, 4, 1-4 (2014)
Soluble peptide treatment reverses CD8 T-cell-induced disease in a mouse model of spontaneous tissue-selective autoimmunity
Paek SY, et al.
The Journal of Investigative Dermatology, 132(3), 677-686 (2012)
Marie Jo Halaby et al.
Science immunology, 4(42) (2019-12-15)
General control nonderepressible 2 (GCN2) is an environmental sensor controlling transcription and translation in response to nutrient availability. Although GCN2 is a putative therapeutic target for immuno-oncology, its role in shaping the immune response to tumors is poorly understood. Here
Primary in vivo responses to ovalbumin. Probing the predictive value of the Kb binding motif.
Lipford GB, et al.
Journal of Immunology, 150(4), 1212-1222 (1993)
Dead Tumor Cells Expressing Infectious Salmon Anemia Virus Fusogenic Protein Favor Antigen Cross-Priming In Vitro
Morales J, et al.
Frontiers in immunology, 8, 1170-1170 (2017)
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