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SAB4200663

Sigma-Aldrich

Anti-Copeptin antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
CT-proAVP
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

species reactivity

human

concentration

~1 mg/mL

technique(s)

immunoblotting: 0.25-0.5  μg/mL (recommended using recombinant human Copeptin trifluoroacetate)
immunohistochemistry: 20 μg/mL (recommended using mouse or human kidney sections)
immunoprecipitation (IP): 5-10 μg (recommended using recombinant human Copeptin trifluoroacetate (C8749).)
indirect ELISA: 0.25-0.5  μg/mL (recommended using human Copeptin trifluoroacetate (C8749) for coating.)

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... AVP(551)

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This Item
SAB4200494L3410L8793
species reactivity

human

species reactivity

human

species reactivity

mouse, human

species reactivity

mouse, human, rat

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

technique(s)

immunoblotting: 0.25-0.5  μg/mL (recommended using recombinant human Copeptin trifluoroacetate), immunoprecipitation (IP): 5-10 μg (recommended using recombinant human Copeptin trifluoroacetate (C8749).), immunohistochemistry: 20 μg/mL (recommended using mouse or human kidney sections), indirect ELISA: 0.25-0.5  μg/mL (recommended using human Copeptin trifluoroacetate (C8749) for coating.)

technique(s)

western blot: 5-10 μg/mL using formalin-fixed paraffin-embedded human pancreas.

technique(s)

indirect ELISA: 1:1,000 using human or mouse recombinant leptin, microarray: suitable, western blot: 1:5,000 using human recombinant leptin

technique(s)

immunoprecipitation (IP): 5-10 μg using extracts of human U87 cells, western blot: 0.5-1 μg/mL using whole extracts of rat and mouse brain

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

concentration

~1 mg/mL

concentration

~1.0 mg/mL

concentration

-

concentration

~1 mg/mL

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General description

AVP or pre-proAVP, also known as, vasopressin-neurophysin 2-copeptin is one of the main hormones of the axis hypothalamic-pituitary adrenal. It is split into 3 chains: Arg-vasopressin, neurophysin-2 and copeptin. Copeptin is a glycopeptide with 39 amino acids, located at the C-terminal part of the pre-proAVP. It is secreted by the posterior pituitary gland and poured into the systemic circulation.
The gene AVP (arginine vasopressin) is mapped to human chromosome 20. It is an antidiurectic hormone which is produced by hypothalamic neurons.

Immunogen

a synthetic peptide corresponding to the C-terminal region of human Copeptin

Application

Anti-Copeptin antibody produced in rabbit has been used in various immunochemical techniques including :
  • immunohistochemistry
  • immunoblotting
  • immunoprecipitation
  • enzyme linked immunosorbent assay (ELISA)

Biochem/physiol Actions

Copeptin concentration directly reflects AVP activation and serves as a biomarker of the AVP system. Altered copeptin levels are implicated in stroke, sudden death and cardiovascular events. It can also be used as a biomarker for a list of illnesses, such as acute myocardial infarction (AMI), vasodilatory shock, metabolic syndrome, diabetes insipidus, diabetes mellitus, sepsis, septic shock, lower respiratory tract infections, hyponatremia, acute dyspnea, autosomal dominant polycystic kidney disease (ADPKD), intracerebral hemorrhage, pulmonary arterial hypertension (PAH) and head injury.
The gene AVP (arginine vasopressin) encodes preprovasopressin which is processed into vasopressin, neurophysin II and glycoprotein (copeptin). Mutations in it are associated with neurohypophyseal diabetes insipidus. It also plays a crucial role in social mannerism, such as recognition, aggression, reproduction and parenting. The levels of circulating copeptin is higher in children suffering from febrile seizures.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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Jia Jia Liu et al.
PloS one, 10(8), e0136436-e0136436 (2015-08-22)
Arginine vasopressin (AVP) plays a role in social behavior, through receptor AVPR1A. The promoter polymorphism AVPR1A RS3 has been associated with human social behaviors, and with acute response to stress. Here, the relationships between AVPR1A RS3, early-life stressors, and social
Copeptin and its potential role in diagnosis and prognosis of various diseases
Dobvsa L and Cullen EK
Biochemical Medicine, 23(2), 172-190 (2013)
Benjamin Stöcklin et al.
PloS one, 10(4), e0124663-e0124663 (2015-04-22)
Accurate diagnosis of febrile seizures in children presenting after paroxysmal episodes associated with fever, is hampered by the lack of objective postictal biomarkers. The aim of our study was to investigate whether FS are associated with increased levels of serum
Circulating levels of copeptin predict outcome in patients with pulmonary arterial hypertension
Nickel NP, et al.
Respiratory Research, 14(1), 130-130 (2013)
M Ito et al.
The Journal of clinical investigation, 91(6), 2565-2571 (1993-06-01)
A transition of G to A at nucleotide position 279 in exon 1 of the vasopressin gene has been identified in patients with familial central diabetes insipidus. The mutation predicts an amino acid substitution of Thr (ACG) for Ala (GCG)

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