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SAB4501062

Sigma-Aldrich

Anti-GABA-B Receptor antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
G protein-coupled receptor 51, GABA-B RECEPTOR, GABABR2, GPR51, R2 SUBUNIT
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 108 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GABBR1(2550)

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This Item
SAB4501063G9920SAB4501061
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

Gene Information

human ... GABBR1(2550)

Gene Information

human ... GABBR1(2550)

Gene Information

rat ... Gabbr2(83633)

Gene Information

human ... GAB1(2549)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

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General description

Anti-GABA-B Receptor Antibody detects endogenous levels of total GABA-B Receptor protein.
The γ-aminobutyric acid type B (GABAB) receptor is coded by the GABBR1 gene. It has 22 exons and spans at least 18 kb. GABAB gene is present between an olfactory receptor gene cluster downstream and the HLA (human leukocyte antigen) class I region upstream. It is mapped to human chromosome 6p22.

Immunogen

The antiserum was produced against synthesized peptide derived from human GABA-B Receptor.

Immunogen Range: 871-920

Biochem/physiol Actions

The γ-aminobutyric acid type B (GABAB) is essential for the initiation by agonists like GABA (gamma-aminobutyric acid ). GABAB receptors participates in response habituation. In the visual cortex, GABAB is also involved in the initiation of orientation tuning in conjunction with GABAA receptors.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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Li Z, et al.
Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, 25(6), 517-524 (2016)
GABBR 1 and SLC 6A1, Two Genes Involved in Modulation of GABA Synaptic Transmission, Influence Risk for Alcoholism: Results from Three Ethnically Diverse Populations.
Enoch MA, et al.
Alcoholism, Clinical and Experimental Research, 40(1), 93-101 (2016)
Different roles for GABAA and GABAB receptors in visual processing in the rat superior colliculus.
Binns KE and Salt TE
The Journal of Physiology, 504(3), 629-639 (1997)
GABBR1 has a HERV-W LTR in its regulatory region?a possible implication for schizophrenia.
Hegyi H.
Biology Direct, 8(1), 5-5 (2013)

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