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SAB5500087

Sigma-Aldrich

Anti-COX2 antibody, Rabbit monoclonal

clone SP21, recombinant, expressed in proprietary host, tissue culture supernatant

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NACRES:
NA.41

biological source

rabbit

Quality Level

recombinant

expressed in proprietary host

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

SP21, monoclonal

species reactivity

human (tested)

species reactivity (predicted by homology)

mouse, frog, bovine, rat, dog

technique(s)

immunohistochemistry: 1:100

isotype

IgG

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... PTGS2(5743)

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This Item
SAB5600153SAB5700721HPA001335
biological source

rabbit

biological source

-

biological source

rabbit

biological source

rabbit

conjugate

unconjugated

conjugate

-

conjugate

-

conjugate

unconjugated

species reactivity

human (tested)

species reactivity

human

species reactivity

rat, mouse, human

species reactivity

human

clone

SP21, monoclonal

clone

RM348, monoclonal, recombinant monoclonal

clone

polyclonal

clone

polyclonal

Gene Information

human ... PTGS2(5743)

Gene Information

human ... PTGS2(5743)

Gene Information

human ... PTGS2(5743)

Gene Information

human ... PTGS2(5743)

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General description

COX-2 (Cyclooxygenase-2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX-2 is therefore of interest in studying immune response regulation. COX-2 is induced by a wide variety of stimuli and was initially identified as immediate-early growth response gene. In addition, COX-2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX-1 levels remain unchanged.

Immunogen

Synthetic peptide corresponding to C-terminus of rat COX-2.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Manyi Sun et al.
Molecular medicine reports, 23(2) (2020-12-11)
Neuropathic pain is induced by primary injury and dysfunction of the nervous system, and is accompanied by the activation of inflammation signaling pathways. Yin Yang 1 (YY1) is reported to be involved in inflammation; however, its role in the development of neuropathic
Yoshihiro Watanabe et al.
American journal of translational research, 12(3), 1096-1113 (2020-04-10)
Cyclooxygenase-2 (Cox-2) has been shown to promote cancer initiation and progression through pleiotropic functions including induction of epithelial-to-mesenchymal transition (EMT) via its predominant product prostaglandin E2 that binds to the cognate receptor EP2. Hence, pharmacological inhibition at the level of

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