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SAB5500192

Sigma-Aldrich

Anti-Vinculin Antibody

rabbit monoclonal, SP117

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

Product Name

Anti-Vinculin antibody, Rabbit monoclonal, clone SP117, recombinant, expressed in proprietary host, affinity isolated antibody

biological source

rabbit

Quality Level

100

recombinant

expressed in proprietary host

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

SP117, monoclonal

species reactivity

human (tested)

species reactivity (predicted by homology)

chicken, rat, pig, dog, mouse

General description

Vinculin is a muscle-specific cytoskeletal protein associated with the cytoplasmic faces of both cell-cell and cell extracellular matrix adherens type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane and regulating cell-surface E-cadherin expression. The defect of this protein can cause dilated cardiomyopathy

Immunogen

Synthetic peptide derived from C-terminus of human vinculin protein.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Description
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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
160406LVD

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Indrajyoti Indra et al.
Molecular biology of the cell, 32(19), 1824-1837 (2021-07-15)
Desmosomes (DSMs), together with adherens junctions (AJs) and tight junctions (TJs), constitute the apical cell junctional complex (AJC). While the importance of the apical and basolateral polarity machinery in the organization of AJs and TJs is well established, how DSMs

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