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SAE0149

Sigma-Aldrich

Artificial Saliva for Pharmaceutical Research

Synonym(s):

Artificial Saliva Solution, Saliva Substitute

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About This Item

UNSPSC Code:
51241229
NACRES:
NA.25
Pricing and availability is not currently available.

shipped in

wet ice

storage temp.

2-8°C

General description

Artificial saliva helps in gaining a stable environment and standardized procedures for in vitro and in vivo studies in pharmacological and bioengineering fields. This saliva mimics the properties of natural saliva in terms of chemical composition and physical characteristics.[1] Artificial Saliva is formulated according to literature for pharmaceutical research such as studies of drug dissolution and drug delivery through the oral mucosa.

Application

Artificial Saliva for pharmaceutical research has been used:

  • to study the antifungal activity of Candida albicans on the surface of printed denture resin discs[2]
  • as a diluting agent for inactivation of Escherichia coli in droplets are with different ambient humidities[3]
  • to determine the stability of graphene oxide-amoxicillin (GO-AMOX) capsules[4]

Preparation Note

Sodium Chloride
Potassium Phosphate Monobasic
Potassium Chloride
Potassium Thiocyanate Urea

Storage and Stability

This is a ready to use formulation that should be stored refrigerated.

Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW8425
MKCW7224
MKCV5695
MKCV5575
MKCT7253

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J J Pytko-Polonczyk et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 68(6), 807-813 (2018-03-20)
Examination of dental materials and their properties at the initial stage of the digestive process requires the development of conditions that mimic the environment of the oral cavity. One of the main components of this area is saliva, where many
Inactivation of Escherichia coli in droplets at different ambient relative humidities: Effects of phase transition, solute and cell concentrations
Liang Z, et al.
Atmospheric Environment, 119066-119066 (2022)
Sol Jeon et al.
Journal of dentistry, 120, 104098-104098 (2022-03-25)
To produce three-dimensionally (3D) printed removable denture bases with antifungal activity using microencapsulation of phytochemicals that inhibit Candida albicans growth. Two types of phytoncide oil extract A and B were micro-encapsulated. The phytoncide-filled microcapsules were mixed with denture base resin
Anna Trusek et al.
Materials (Basel, Switzerland), 14(12) (2021-07-03)
Graphene oxide (GO) was proposed as an efficient carrier of antibiotics. The model drug, amoxicillin (AMOX), was attached to GO using a peptide linker (Leu-Leu-Gly). GO-AMOX was dispersed in a hydrogel to which the enzyme responsible for releasing AMOX from

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