SBR00067
Rifampicin Water Soluble
solubility: 50 mg/mL in water, freely soluble
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form
solid
Quality Level
specific activity
(Antibacterial)
solubility
water: freely soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
viruses
mode of action
protein synthesis | interferes
storage temp.
−20°C
General description
Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. Rifampicin is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, and primary biliary cirrhosis (PBC). Rifampicin was also found active by inhibiting Tau Oligomer Propagation in Alzheimer’s disease. In addition, Rifampicin is used as a selection agent for agrobacterium mediated plant transformation.
Application
Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.
Biochem/physiol Actions
Rifampicin inhibits the assembly of DNA and protein into mature virus particles. It inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase, which results in cell death.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. Inhibits the assembly of DNA and protein into mature virus particles.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. Inhibits the assembly of DNA and protein into mature virus particles.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Specific packaging of custom RNA molecules into cowpea mosaic virus-like particles.
Recombinant proteins from plants: production and isolation of clinically useful compounds, 103-111 (2022)
Treatment of rifampicin-resistant tuberculosis disease and infection in children: key updates, challenges and opportunities
Pathogens (Basel, Switzerland), 11.4, 381-381 (2022)
Biomedicines, 10(2), 297-297 (2022-02-26)
The cell-to-cell transmission of tau aggregates is considered a mechanism underlying the intracerebral spreading of tau pathology in Alzheimer's disease (AD) and other tauopathies. Recent studies suggest that tau oligomers, rather than fibrils, participate in this process. We previously showed
Guidelines for the Management of Cholestatic Liver Diseases (2021)
Journal of clinical and translational hepatology (2022)
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