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Key Documents

SCP0021

Sigma-Aldrich

Angiotensinogen 1-14 Renin Substrate porcine

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About This Item

Empirical Formula (Hill Notation):
C85H123N21O20
Molecular Weight:
1759.01
UNSPSC Code:
12352200
NACRES:
NA.32

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥70%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser

Application

Renin (angiotensinogenase) which hydrolyzes angiotensinogen is a component of the renin-angiotensin system (RAS) that regulates vasoconstriction and blood pressure. Angiotensinogen 1-14 (DRVYIHPFHLLVYS) may be used as a substrate for renin. A variety of renin substrates may be built around the minimal sequence His-Pro-Phe-His-Leu-Leu-Val-Tyr (HPFHLLVY).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Sining Leng et al.
Nature communications, 11(1), 1680-1680 (2020-04-05)
Rosettes are widely used in epithelial morphogenesis during embryonic development and organogenesis. However, their role in postnatal development and adult tissue maintenance remains largely unknown. Here, we show zona glomerulosa cells in the adult adrenal cortex organize into rosettes through

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