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SCP0237

Sigma-Aldrich

PAR-1 Selective Agonist

≥95% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C31H53N9O6
Molecular Weight:
647.81
UNSPSC Code:
12352200
NACRES:
NA.32

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥65%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Thr-Phe-Leu-Leu-Arg-NH2

Application

PAR-1 selective agonist has been used for platelet aggregation.
Thr-Phe-Leu-Leu-Arg-NH2 (TFLLR-NH2) is used as a selective agonist for protease-activated receptor 1 (PAR1) which is involved in the development of cardiac remodeling and hypertrophy after myocardial injury.

Biochem/physiol Actions

Protease-activated receptor-1 (PAR-1) is a G protein-coupled receptor, that is activated through thrombin and other proteases.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rac Regulates the TRAP-Induced Release of Phosphorylated-HSP27 from Human Platelets via p38 MAP Kinase but Not JNK
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High-resolution crystal structure of human protease-activated receptor 1
Zhang C, et al.
Nature, 492(7429), 387-387 (2012)

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