SMB00801
Lipopolysaccharides from Proteus vulgaris
purified by phenol extraction
Synonym(s):
LPS
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About This Item
UNSPSC Code:
12352211
NACRES:
NA.28
Recommended Products
biological source
bacterial (Proteus vulgaris)
Quality Level
form
lyophilized powder
purified by
phenol extraction
impurities
≤3% Protein (Lowry)
color
white to yellow cast
solubility
water: 4.90-5.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow
shipped in
ambient
storage temp.
2-8°C
General description
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. They consist of lipid A moiety linked to an antigenic O-polysaccharide.
Proteus vulgaris is a rod-shaped Gram-negative, facultative anaerobe bacterium. It inhabits the intestinal tract of humans and animals and can be found in soil, water and feces. P. vulgaris is a member of the Enterobacteriaceae family which are opportunistic pathogens in humans, responsible for urinary tract and burn infections.
The chemical structures of LPS from Proteus sp. are different from each other.
Proteus vulgaris is a rod-shaped Gram-negative, facultative anaerobe bacterium. It inhabits the intestinal tract of humans and animals and can be found in soil, water and feces. P. vulgaris is a member of the Enterobacteriaceae family which are opportunistic pathogens in humans, responsible for urinary tract and burn infections.
The chemical structures of LPS from Proteus sp. are different from each other.
Biochem/physiol Actions
LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular patterns (PAMPs). Different chemical structures of LPS can be associated with the virulence and pathogenesis of the bacteria. It has been reported that the LPS chemical structure from P. vulgaris can influence the crystallization of mineral urine components (such as calcium and magnesium), resulting in stone formation in the kidney. Antibodies produced in rickettsial infections were found to react with LPS from Proteus vulgaris and Proteus mirabilis. This phenomenon allows the purified LPS from these two species to serve as a tool for the diagnosis of rickettsiosis (scrub typhus, caused by the bacterium Orientia sp.) in the Weil-Felix test.
Other Notes
To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
related product
Product No.
Description
Pricing
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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LPS/TLR4 signal transduction pathway
Lu, Y.C., Yeh, W.C., Ohashi, P.S.
Cytokine, 42, 145-151 (2008)
A Torzewska et al.
FEMS immunology and medical microbiology, 31(3), 227-234 (2001-11-27)
The O-specific polysaccharide (O-antigen) of the lipopolysaccharide (LPS) of Proteus vulgaris O37 was studied by (1)H and (13)C nuclear magnetic resonance spectroscopy before and after O-deacetylation and found to be structurally similar to that of P. vulgaris O46 studied earlier.
S Mizushiri et al.
Microbiology and immunology, 34(2), 121-133 (1990-01-01)
The lipopolysaccharides (LPS) extracted from Proteus strains OX2, OX19, and OXK used as antigens in the Weil-Felix test, were characterized by chemical analysis and SDS-polyacrylamide gel electrophoresis (SDS-PAGE). To separate the O-polysaccharide, core-oligosaccharide, and lipid A moieties, each LPS was
Generation and characterization of a lipopolysaccharide-specific murine monoclonal antibody to Proteus vulgaris OX19
Bakshi, D., Jain, R., Tuteja, U., Batra, H.V.
World Journal of Microbiology & Biotechnology, 23, 817-821 (2007)
D J HOSSACK
British journal of pharmacology and chemotherapy, 19, 306-312 (1962-10-01)
Ascending urinary tract infections with stone formation have been produced experimentally in rats, using a modification of the method of Vermuelen & Goetz (1954a, b). A zinc disc infected with a culture of Proteus vulgaris was inserted into the bladder
Articles
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