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SML0271

Sigma-Aldrich

VER-155008

≥98% (HPLC)

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Synonym(s):
5′-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
Empirical Formula (Hill Notation):
C25H23Cl2N7O4
CAS Number:
Molecular Weight:
556.40
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to light brown

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Nc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc5ccc(Cl)c(Cl)c5)nc12

InChI

1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1

InChI key

ZXGGCBQORXDVTE-UMCMBGNQSA-N

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This Item
SML1967SML2340SML1516
VER-155008 ≥98% (HPLC)

Sigma-Aldrich

SML0271

VER-155008

SGC8158 ≥98% (HPLC)

Sigma-Aldrich

SML2340

SGC8158

DS-437 ≥98% (HPLC)

Sigma-Aldrich

SML1516

DS-437

form

powder

form

powder

form

powder

form

powder

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

color

white to light brown

color

white to beige

color

white to beige

color

white to beige

solubility

DMSO: >10 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Application

VER-155008 has been used as a heat shock protein 70 (HSP70) inhibitor:
  • to study its effects on human embryonic kidney 293 (HEK293T) cells
  • to study its effects on viral mRNA synthesis and protein expression in Vero E6 cells
  • to determine its effects on the attenuation of seizures in rats

Biochem/physiol Actions

VER-155002 is a small molecule, ATP-derivative inhibitor of HSP70 (IC50 = 500 nM). The compound inhibits proliferation of several colon and breast cancer cell lines, induces caspase dependent apoptosis in BT474 cells and down regulates expression of Her2 and Raf-1 in HCT116 cells.
VER‐155008 positively promotes memory recovery and axonal regrowth. It is also involved in inhibiting cell cycle progression and proliferation in non-small-cell lung cancer (NSCLC).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Virology, 553, 70-80 (2020-11-27)
Many viruses utilize molecular chaperone heat shock protein 90 (Hsp90) for protein folding and stabilization, however, the role of Hsp90 in herpesvirus lifecycle is obscure. Here, we provide evidence that Hsp90 participates in pseudorabies virus (PRV) replication. Viral growth kinetics
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