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Key Documents

SML0664

Sigma-Aldrich

LM11A-31 dihydrochloride

≥95% (HPLC)

Synonym(s):

2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]-pentanamide dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H25N3O2 · 2HCl
CAS Number:
Molecular Weight:
316.27
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77

assay

≥95% (HPLC)

form

oil

storage condition

desiccated

color

colorless to yellow

storage temp.

2-8°C

SMILES string

Cl.Cl.CCC(C)C(N)C(=O)NCCN1CCOCC1

InChI

1S/C12H25N3O2.2ClH/c1-3-10(2)11(13)12(16)14-4-5-15-6-8-17-9-7-15;;/h10-11H,3-9,13H2,1-2H3,(H,14,16);2*1H

InChI key

LLIHJRRZJDEKLB-UHFFFAOYSA-N

Application

LM11A-31 dihydrochloride has been used to study the effect of p75 neurotrophin receptor (p75 NTR) blockade, by non-peptide LM11A-31 ligand, on PC12 cell viability.

Biochem/physiol Actions

LM11A-31 is a non-peptide ligand of the p75 neurotrophin receptor (p75NTR). LM11A-31 blocks pro-NGF induced cell death in neuronal cultures, and protects neuronal cells from the the cytotoxic effects of cisplatin or methotrexate. Oral administration of LM11A-31 promotes the survival of oligodendrocytes and myelinated axons in a mouse spinal cord injury model and improves function in both weight-bearing and non-weight bearing tests.

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Warning

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Different responses of PC12 cells to different pro-nerve growth factor protein variants
Soligo M, et al.
Neurochemistry International, 129, 104498-104498 (2019)
Marzia Soligo et al.
Neurochemistry international, 129, 104498-104498 (2019-07-07)
The present work aimed to explore the innovative hypothesis that different transcript/protein variants of a pro-neurotrophin may generate different biological outcomes in a cellular system. Nerve growth factor (NGF) is important in the development and progression of neurodegenerative and cancer
Valentina Pallottini et al.
Cells, 9(10) (2020-10-08)
Despite its undisputable role in the homeostatic regulation of the nervous system, the nerve growth factor (NGF) also governs the relevant cellular processes in other tissues and organs. In this study, we aimed at assessing the expression and the putative

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