Name: SF1670
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₇NO₃

CAS Number:

345630-40-2

Molecular Weight:

307.34

UNSPSC Code:

12352200

NACRES:

NA.77

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

, light pink to red to very dark purple

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

N(c1cc2c(cc1)c3c(cccc3)C(=O)C2=O)C(=O)C(C)(C)C

InChI

1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)

InChI key

VZQDDSYKVYARDW-UHFFFAOYSA-N

Application

SF1670 has been used:

To study the effect of microRNA-30a on PTEN (phosphatase and tensin homologue deleted on chromosome 10 ) expression regulation.
To study the formation of autophagosomes, induced by EGF (Epidermal growth factor) - dependent PTEN expression.
To study the role of PTEN in the regulation of autophagy induction in human normal endometrial stromal cells.

Biochem/physiol Actions

PTEN prevents PI3-K(phosphoinositide 3-kinase)/Akt signaling pathway, which is very essential for neuronal regeneration. Therefore, inhibition of PTEN by SF1670 may support neuronal regeneration.

SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor with an IC₅₀ of 2 micromolar. PTEN inhibition by SF1670 was shown to increase neutrophil activity (polarization, phagocytosis, oxidative burst, and recruitment to site of infection), thereby enhancing the inflammatory response and bacteria-killing capacity of neutopenic mice.

SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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