SML0684

SF1670

≥98% (HPLC)

• Synonym(s): N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide, N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethylpropionamide
• Empirical Formula (Hill Notation): C₁₉H₁₇NO₃
• CAS Number: 345630-40-2
• Molecular Weight: 307.34
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , light pink to red to very dark purple
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• InChI: 1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)
• InChI key: VZQDDSYKVYARDW-UHFFFAOYSA-N

Description

Application

SF1670 has been used:

• To study the effect of microRNA-30a on PTEN (phosphatase and tensin homologue deleted on chromosome 10 ) expression regulation.
• To study the formation of autophagosomes, induced by EGF (Epidermal growth factor) - dependent PTEN expression.
• To study the role of PTEN in the regulation of autophagy induction in human normal endometrial stromal cells.

Biochem/physiol Actions

PTEN prevents PI3-K(phosphoinositide 3-kinase)/Akt signaling pathway, which is very essential for neuronal regeneration. Therefore, inhibition of PTEN by SF1670 may support neuronal regeneration.

SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor with an IC₅₀ of 2 micromolar. PTEN inhibition by SF1670 was shown to increase neutrophil activity (polarization, phagocytosis, oxidative burst, and recruitment to site of infection), thereby enhancing the inflammatory response and bacteria-killing capacity of neutopenic mice.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable