All Photos(1)
Synonym(s):
3,5-Diethyl 4-{2-[(1E)-3-(tert-butoxy)-3-oxoprop-1-en-1-yl]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, 4-[2-[(1E)-3-(1,1-Dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-diethyl ester, CID 5311217, GR-43659X, GX-1048
Empirical Formula (Hill Notation):
C26H33NO6
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
InChI
1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+
InChI key
GKQPCPXONLDCMU-CCEZHUSRSA-N
Biochem/physiol Actions
Lacidipine is a long-acting calcium antagonist that is used in the management of hypertension. Lacidipine is a L-type Ca(2+) channel blocker belonging to 1,4-dihydropyridine class. Also, Lacidipine inhibits ryanodine receptors on the ER membrane that enhances folding, trafficking and lysosomal activity of ERAD (ER-associated degradation) misfolded lysosomal glucocerebrosidase (GS).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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A Dasgupta et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 29(2), 239-243 (2009-12-17)
The cardiovascular drug lacidipine (Lc) is known to possess antibacterial activity. Further potentiation of action is possible by synergism between Lc and an antibiotic or a non-antibiotic. The minimum inhibitory concentration (MIC) of antibiotics, Lc and other non-antibiotics were detected
Ileana Lulić et al.
Lijecnicki vjesnik, 133(3-4), 98-100 (2011-05-27)
The sense of smell plays an important role in the maintenance of a good quality of life. Disturbances of olfactory sense include complete or partial loss of smell, distortion of smell, and perceived smell in the absence of real stimuli.
Yasin Bayir et al.
Cardiovascular toxicology, 12(2), 166-174 (2012-02-10)
In this study, the effects of lacidipine (LAC), ramipril (RAM), and valsartan (VAL) on biochemical and histopathologic changes in heart tissue were studied in rats with isoproterenol-induced (ISO-induced) myocardial infarction (MI). LAC, RAM, and VAL had been administered via oral
Mingyu Sun et al.
Drug development and industrial pharmacy, 38(9), 1099-1106 (2011-12-23)
In this study, a new discriminative dissolution condition for lacidipine tablets was developed by the established in vitro-in vivo relationship. Series of dissolution media of phosphate buffer solution (PBS) covering the pH range of 1-7.2 and pH 6.8 PBS containing
Janardhan Singh et al.
Archives of physiology and biochemistry, 117(1), 12-17 (2010-11-26)
The present study was planned to evaluate the effects of lacidipine on STZ induced diabetic neuropathy. Streptozotocin (STZ) induced diabetic neuropathy in rats was monitored by measuring blood sugar levels, motor nerve conduction velocity (MNCV), nociception and histopathology of tibial
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