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SML0982

Sigma-Aldrich

Astaxanthin

≥97% (HPLC), from Blakeslea trispora

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Synonym(s):
3,3′-Dihydroxy-β-carotene-4,4′-dione, trans-Astaxanthin
Empirical Formula (Hill Notation):
C40H52O4
CAS Number:
Molecular Weight:
596.84

biological source

Blakeslea trispora

Quality Level

assay

≥97% (HPLC)

form

powder

storage condition

desiccated
protect from light

color

, pink to very dark purple

solubility

DMSO: 1 mg/mL (warmed)

storage temp.

−20°C

InChI

1S/C40H52O4/c1-27(17-13-19-29(3)21-23-33-31(5)37(43)35(41)25-39(33,7)8)15-11-12-16-28(2)18-14-20-30(4)22-24-34-32(6)38(44)36(42)26-40(34,9)10/h11-24,35-36,41-42H,25-26H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,27-15+,28-16+,29-19+,30-20+/t35-,36-/m0/s1

InChI key

MQZIGYBFDRPAKN-UWFIBFSHSA-N

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This Item
P04534165952991
Astaxanthin ≥97% (HPLC), from Blakeslea trispora

SML0982

Astaxanthin

Piceatannol powder

P0453

Piceatannol

all-trans-Astaxanthin analytical standard

41659

all-trans-Astaxanthin

13-cis-Astaxanthin analytical standard

52991

13-cis-Astaxanthin

form

powder

form

powder

form

-

form

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−70°C

solubility

DMSO: 1 mg/mL (warmed)

solubility

H2O: 0.5 mg/mL, DMSO: 10 mg/mL, ethanol: 10 mg/mL

solubility

-

solubility

-

storage condition

desiccated, protect from light

storage condition

-

storage condition

-

storage condition

-

biological source

Blakeslea trispora

biological source

-

biological source

-

biological source

-

General description

Astaxanthin (AST) is a red dietary carotenoid. It is mainly found in aquatic animals and microalgae, such as Haematococcus pluvialis and Chlorella zofingiensis.

Application

Astaxanthin has been used:
  • as an antioxidant to study its effect on Brachionus manjavacas (Rotifera) population growth
  • to study its effects on the treatment of diabetic retinopathy.
  • to investigate its role in restoring the expression of Nrf2 (nuclear factor erythroid 2 p45-related factor 2) and glutathione S-transferase P1 (GSTP1) through epigenetic modification in human prostate LNCaP cells.

Biochem/physiol Actions

In vivo and in vitro studies propose that astaxanthin (AST) possesses health-promoting activities, signifying its potential use in the prevention of various diseases, such as cancers and Parkinson′s disease. Due to its bright red colour, AST has been used as a food colorant in animal feeds.
Astaxanthin is a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. Astaxanthin protects against oxidative stress, inhibiting NF-KB, suppressing pro-inflammatory genes and suppressing production of pro-inflammatory compounds nitric oxide, prostaglandin E2, TNF-α, and interleukin-1β. Astaxanthin′s protection of cells from oxidative stress generated by TNF-α and palmitate has been shown to ameliorate insulin resistance. Astaxanthin has also been shown to be an inhibitor of PPARγ.

Other Notes

Light and air sensitive

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Sigma-Aldrich

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β-Carotene

Chengzhen Liu et al.
Journal of agricultural and food chemistry, 67(18), 5113-5121 (2019-04-24)
Astaxanthin, a hydrophobic carotenoid found in marine plants and animals, is claimed to exhibit various beneficial biological activities. Its use as a nutraceutical in foods, however, is currently limited by its low water-solubility and poor bioavailability. The goal of this
Yingsong Zhou et al.
Nutrients, 11(6) (2019-06-05)
Exercise-induced reactive oxygen and nitrogen species are increasingly considered as beneficial health promotion. Astaxanthin (ASX) has been recognized as a potent antioxidant suitable for human ingestion. We investigated whether ASX administration suppressed antioxidant enzyme activity in moderate-intensity exercise. Seven-week-old male
Ningyang Li et al.
Applied microbiology and biotechnology, 104(16), 6977-6989 (2020-07-01)
This study aimed to develop a bioprocess using plant oil as the carbon source for lipid-assimilating yeast to produce high-value astaxanthin. Using high-oleic safflower oil as a model, efficient cell growth and astaxanthin production by the engineered Yarrowia lipolytica strain
Effect of astaxanthin on retinal pigment epithelial cells in high glucose: an in-vitro study.
Fu D and Tian X, et al.
Biomedical Research, 28(15) (2017)
Epigenetic CpG methylation of the promoter and reactivation of the expression of GSTP1 by Astaxanthin in human prostate LNCaP cells.
Yang Y, et al.
The AAPS Journal, 19(2), 421-430 (2017)

Protocols

HPLC Analysis of Carotene Compounds on Ascentis® RP-Amide

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