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SML1005

Sigma-Aldrich

NSC 617145

≥98% (HPLC)

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Synonym(s):
(2,3-Propandiyl-bis(2,3-dichloro)maleimide, 1,1′-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-Pyrrole-2,5-dione, NSC-617145, SID 487795
Empirical Formula (Hill Notation):
C13H10Cl4N2O4
CAS Number:
Molecular Weight:
400.04
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 3 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C13H10Cl4N2O4/c1-13(2,3-18-9(20)5(14)6(15)10(18)21)4-19-11(22)7(16)8(17)12(19)23/h3-4H2,1-2H3

InChI key

PCOXPBOKDABARQ-UHFFFAOYSA-N

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This Item
D0633SML1274SML0819
vibrant-m

SML1005

NSC 617145

vibrant-m

D0633

7-(2,3-Dihydroxypropyl)theophylline

vibrant-m

SML1274

RI-1

vibrant-m

SML0819

Bisdionin C

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

color

white to light brown

color

-

color

yellow to orange

color

white to beige

solubility

DMSO: 3 mg/mL, clear (warmed)

solubility

-

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 1 mg/mL, clear (warmed)

Biochem/physiol Actions

NSC 617145 has an IC50 value of 230nM.
NSC 617145 is a potent and cell-permeable inhibitor of Werner syndrome helicase (WRN) that causes accumulation of double-strand breaks (DSB) and chromosomal abnormalities in cancer cells.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Articles

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

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