SML1623

MSP-3

≥98% (HPLC)

• Synonym(s): N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide
• Empirical Formula (Hill Notation): C₁₆H₁₉NO₃S
• CAS Number: 1820968-63-5
• Molecular Weight: 305.39
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825508
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: oil
• color: white to beige
• storage temp.: room temp
• SMILES string: O=C(NCC1=CC=C(O)C(OC)=C1)CCCC2=CC=CS2
• InChI: 1S/C16H19NO3S/c1-20-15-10-12(7-8-14(15)18)11-17-16(19)6-2-4-13-5-3-9-21-13/h3,5,7-10,18H,2,4,6,11H2,1H3,(H,17,19)
• InChI key: HCUVEUVIUAJXRB-UHFFFAOYSA-N

Description

Biochem/physiol Actions

MSP-3 is a Transient Receptor Potential Vanilloid Type-1 (TRPV1) channel agonist with antioxidant and neuroprotective activity. MSP-3 activated TRPV1 channels with similar efficacy as compared to capsaicin (EC50 = 870 nM). It protected a keratinocyte cell line from oxidative stress damage with more efficacy than capsaicin and prevented the damage caused by H2O2 in differentiated human neuroblastoma cell lines as well as in rat cortical slices.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable