SML1625

Gemifloxacin mesylate

≥98% (HPLC)

• Synonym(s): 7-(4-Aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydro-1,8-naphthyridine-3-carboxylic acid mesylate, 7-[(4Z)-3-(Aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid monomethanesulfonate
• Empirical Formula (Hill Notation): C₁₈H₂₀FN₅O₄ · CH₄O₃S
• CAS Number: 210353-53-0
• Molecular Weight: 485.49
• MDL number: MFCD08277637
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825509
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to light brown
• solubility: H₂O: 10 mg/mL, clear
• storage temp.: room temp
• SMILES string: CS(=O)(O)=O.OC(C1=CN(C2CC2)C3=NC(N4C/C(C(CN)C4)=N\OC)=C(F)C=C3C1=O)=O
• InChI: 1S/C18H20FN5O4.CH4O3S/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17;1-5(2,3)4/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27);1H3,(H,2,3,4)/b22-14+;
• InChI key: JIYMVSQRGZEYAX-CWUUNJJBSA-N

Description

Biochem/physiol Actions

Gemifloxacin is a broad-spectrum quinolone antibacterial. Fluoroquinolones stabilize DNA strand breaks created by DNA gyrase and topoisomerase IV by binding to the enzyme-DNA complex generating persistent, covalent enzyme–DNA adducts, inhibiting DNA synthesis. Gemifloxacin is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. Gemifloxacin has also been found to inhibit migration and invasion of human colon cancer cells.

Safety Information

• pictograms: GHS08
• signalword: Warning
• hcodes: H341,H361d,H373
• pcodes: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 2 - Repr. 2 - STOT RE 2
• target_organs: Liver
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3