All Photos(1)
Synonym(s):
N3-Cyclopropyl-7-(4-isopropylbenzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine hydrochloride, N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine hydrochloride, SCH79797 xHCl
Empirical Formula (Hill Notation):
C23H25N5 · xHCl
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to light brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
room temp
InChI
1S/C23H25N5.2ClH/c1-14(2)16-5-3-15(4-6-16)13-28-12-11-18-20(28)10-9-19-21(18)22(24)27-23(26-19)25-17-7-8-17;;/h3-6,9-12,14,17H,7-8,13H2,1-2H3,(H3,24,25,26,27);2*1H
InChI key
NNJTXSQXGHYXAJ-UHFFFAOYSA-N
Related Categories
Biochem/physiol Actions
SCH 79797 aids protection during ischemic injury. During subarachnoid hemorrhage (SAH), it plays a key role in the maintenance of microvascular integrity. SCH 79797 also elicits pro‐apoptotic and antiproliferative effects.
SCH 79797 is a nonpeptidic antagonist that targets protease activated receptor-1 (PAR-1) with high affinity (IC50 = 70 nM against 10 nM haTRAP in competitive binding assay; Ki = 35 nM) and selectively inhibits PAR-1 agonists-induced human platelet aggregation (IC50 = 300 nM and 3 μM against 300 nM haTRAP and 0.1 U/mL α-thrombin, respectively), while exhibiting little potency against platelet aggregation induced by ADP, collagen, or PAR-4 agonist γ-thrombin. SCH-79797 is shown to display neuroprotective and antiepileptogenic efficacy in a rat model of lithium/pilocarpine-induced status epilepticus (SE) in vivo (25 μg/kg via daily i.p. 20-30 min after SE termination).
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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SCH 79797, a selective PAR1 antagonist, protects against ischemia/reperfusion-induced arrhythmias in the rat hearts
Mohamed OY, et al.
European Review for Medical and Pharmacological Sciences, 20(22), 4796-4800 (2016)
Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism
Di Serio C, et al.
Basic and Clinical Pharmacology and Toxicology, 101(1), 63-69 (2007)
Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage
Yan J, et al.
Stroke, 44(5), 1410-1417 (2013)
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