SRP4972
GHBP human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE)
Synonym(s):
GH receptor, GHBP, GHR, Somatotropin receptor
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
lyophilized
mol wt
~28.1 kDa
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... GHR(2690)
General description
GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28.1 kDa. GHBP is purified by proprietary chromatographic techniques.
The gene encoding growth hormone receptor (GHR or GHBP) is localized on human chromosome 5p13.1-p12, with nine exons. It possesses a cytoplasmic and an extracellular domain for protein binding.
The gene encoding growth hormone receptor (GHR or GHBP) is localized on human chromosome 5p13.1-p12, with nine exons. It possesses a cytoplasmic and an extracellular domain for protein binding.
Physical form
GHBP was lyophilized from a concentrated (1 mg/ml) solution with 0.0045 mM NaHCO3.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in sterile dH2O not less than 100 μg/ml. This solution can then be diluted into other aqueous buffers.
Certificates of Analysis (COA)
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New molecular mechanisms of GH resistance
European Journal of Endocrinology, 151(1) (2004)
Growth hormone receptor (GHR) gene polymorphism and Prader--Willi syndrome.
Butler M G, et al.
American Journal of Medical Genetics, 161(7), 1647-1653 (2013)
De-Gang Song et al.
Oncotarget, 6(25), 21533-21546 (2015-06-24)
Chimeric antigen receptors (CARs) can redirect T cells against antigen-expressing tumors in an HLA-independent manner. To date, various CARs have been constructed using mouse single chain antibody variable fragments (scFvs) of high affinity that are immunogenic in humans and have
Eric L Carter et al.
The Journal of biological chemistry, 291(5), 2196-2222 (2015-12-17)
Rev-erbα and Rev-erbβ are heme-binding nuclear receptors (NR) that repress the transcription of genes involved in regulating metabolism, inflammation, and the circadian clock. Previous gene expression and co-immunoprecipitation studies led to a model in which heme binding to Rev-erbα recruits
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