SRP6108
Neuron-Specific Enolase human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym(s):
2-phospho-D-glycerate hydro-lyase, ENO2, Enolase 2, Gamma-enolase, NSE, Neural enolase
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About This Item
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biological source
human
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
liquid
mol wt
47 kDa (434 aa, 1-434 aa)
packaging
pkg of 100 μg
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... ENO2(2026)
General description
Enolase enzyme contains three subunits- α, β, and γ-and five isozymes namely αα, ββ γγ, αγ, and βγ. The isozymes that contain a γ subunit are expressed in neuronal and endocrine tissue and are known NSEs (neuron-specific enolases). NSE or γ-enolase is a highly soluble intracellular enzyme, which resides in cytoplasm, and shows predominant expression in neuronal tissues.
Neuron-specific enolase (NSE) is a glycolytic isoenzyme which is located in central and peripheral neurons and neuroendocrine cells. This enzyme is released into the CSF when neural tissue is injured. Neoplasms derived from neural or neuroendocrine tissue may release NSE into the blood. NSE is a useful substance that has been detected in patients with certain tumors, namely - neuroblastoma, small cell lung cancer, medullary thyroid cancer, carcinoid tumors, pancreatic endocrine tumors, and melanoma. NSE shows neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons and binds in a calcium-dependent manner to cultured neocortical neurons promoting cell survival.
Biochem/physiol Actions
Enolases are responsible for catalyzing the catabolism of glycerol in the glycolytic pathway, and NSE catalyzes the conversion of 2-phosphoglycerate into phosphoenolpyruvate. NSE (neuron-specific enolase) is involved in the tumorigenesis of neuroendocrine origin tumors. Patients with multiple myeloma (MM) show elevated NSE serum levels, and these levels might help prognosticate efficiency of chemotherapy and disease progression. In diabetic patients the serum levels of NSE are higher than in normal subjects, and these levels are linked with peripheral neuropathy in diabetic patients. The serum levels of this protein are also elevated in patients with traumatic brain injury and neurodegenerative disease. In young adults, reduced hippocampal GM (gray matter) is related to increased NSE levels in obese individuals, suggesting an association between obesity with a specific marker of neuronal injury in a neurodegeneration and cognitive decline-sensitive brain area.
Physical form
1 mg/mL solution in 20 mM Tris-HCl (pH 7.5) containing 100 mM KCl and 5 mM MgSO4.
Preparation Note
Centrifuge the vial prior to opening.
Other Notes
MSIEKIWARE ILDSRGNPTV EVDLYTAKGL FRAAVPSGAS TGIYEALELR DGDKQRYLGK GVLKAVDHIN STIAPALISS GLSVVEQEKL DNLMLELDGT ENKSKFGANA ILGVSLAVCK AGAAERELPL YRHIAQLAGN SDLILPVPAF NVINGGSHAG NKLAMQEFMI LPVGAESFRD AMRLGAEVYH TLKGVIKDKY GKDATNVGDE GGFAPNILEN SEALELVKEA IDKAGYTEKI VIGMDVAASE FYRDGKYDLD FKSPTDPSRY ITGDQLGALY QDFVRDYPVV SIEDPFDQDD WAAWSKFTAN VGIQIVGDDL TVTNPKRIER AVEEKACNCL LLKVNQIGSV TEAIQACKLA QENGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL MRIEEELGDE ARFAGHNFRN PSVL
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Sonja Rakic et al.
Acta neuropathologica communications, 6(1), 88-88 (2018-09-09)
Clinical studies indicate that systemic infections accelerate cognitive decline in Alzheimer's disease. Animal models suggest that this may be due to enhanced pro-inflammatory changes in the brain. We have performed a post-mortem human study to determine whether systemic infection modifies
Overweight and obesity are associated with neuronal injury in the human cerebellum and hippocampus in young adults: a combined MRI, serum marker and gene expression study.
Mueller K et al
Translational Psychiatry, 2, e200-e200 (2012)
Expression of neuron-specific enolase in multiple myeloma and implications for clinical diagnosis and treatment.
Yang H et al
PLoS ONE, 9(5), e94304-e94304 (2014)
Jianbo Li et al.
Diabetes care, 36(11), 3405-3410 (2013-07-13)
To explore the relationship between serum neuron-specific enolase (NSE) levels and diabetic neuropathy. Type 1 or 2 diabetic and healthy control subjects (n = 568) were randomly enrolled in a cross-sectional study. Diabetic neuropathy status was documented by the presence
Franco Torrente et al.
Journal of pediatric gastroenterology and nutrition, 59(3), 300-307 (2014-05-13)
Allergic colitis shows overlap with classic inflammatory bowel disease (IBD). Clinically, allergic colitis is associated with dysmotility and abdominal pain, and mucosal eosinophilia is characteristic. We thus aimed to characterise mucosal changes in children with allergic colitis compared with normal
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