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SRP6316

Sigma-Aldrich

Antithrombin III from human plasma

≥95% (SDS-PAGE)

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Synonym(s):
SERPINC1
NACRES:
NA.32

biological source

human

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

58 kDa

packaging

pkg of 100 μg
pkg of 500 μg

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... SERPINC1(462)

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This Item
SRP6317SRP6313SRP6260
SERPINA1/A1AT human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

SRP6260

SERPINA1/A1AT human

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

form

lyophilized

form

frozen liquid

form

lyophilized

form

lyophilized powder

shipped in

wet ice

shipped in

dry ice

shipped in

wet ice

shipped in

wet ice

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... SERPINC1(462)

Gene Information

human ... Serpin G1(710)

Gene Information

human ... SERPINF2(5345)

Gene Information

human ... SERPINA1(5265)

General description

SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors. The gene is mapped to human chromosome 1. SerpinC1 is a glycoprotein with three β-sheets and nine α-helices. The protein has an active site region and a heparin binding site.

Biochem/physiol Actions

SerpinC1, also known as antithrombin III (AT III), has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. Antithrombin III synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus, it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. The inhibitory activity of AT III undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. Antithrombin III mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulation of many proinflammatory cytokines. It exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. The deficiency or functional abnormality of AT III may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that AT III can alter or influence inflammatory processes via inhibition of NF (nuclear factor)-κB activation or actin polymerization. It is found in normal serum at 15mg/100mL. Found at higher levels in plasma than in serum because of complexing with thrombin during coagulation. Clinically, reduced levels are indicative of hypercoagulability. Reduction in the levels of antithrombin III enhances the severity of renal ischemia/reperfusion injury.

Physical form

Lyophilized from 50 mM Tris-HCl, pH 8.0, with 150 mM NaCl.

Reconstitution

In water or aqueous buffer

Storage Class

13 - Non Combustible Solids

wgk_germany

nwg


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Customers Also Viewed

Slide 1 of 8

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Plasma antithrombin III and thrombin generation time: correlation with hemoglobin A1 and fasting serum glucose in young diabetic women.
Sowers JR, et al.
Diabetes Care, 3, 655-658 (1980)
Feng Wang et al.
Kidney international, 88(4), 796-803 (2015-06-25)
Antithrombin III, encoded by SerpinC1, is a major anti-coagulation molecule in vivo and has anti-inflammatory effects. We found that patients with low antithrombin III activities presented a higher risk of developing acute kidney injury after cardiac surgery. To study this
Laboratory tests for antithrombin deficiency.
Khor B and Van Cott EM
American Journal of Hematology, 85, 947-950 (2010)
The anti-inflammatory properties of antithrombin III: new therapeutic implications.
Okajima K and Uchiba M
Seminars in Thrombosis and Hemostasis, 24, 27-32 (1998)
Antithrombin III supplementation in severe sepsis: beneficial effects on organ dysfunction.
Inthorn D, et al.
Shock, 8, 328-334 (1997)

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