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T9531

Sigma-Aldrich

D-(+)-Trehalose dihydrate

from Saccharomyces cerevisiae, ≥99%

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Synonym(s):
Trehalose dihydrate, α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside
Empirical Formula (Hill Notation):
C12H22O11 · 2H2O
CAS Number:
Molecular Weight:
378.33
Beilstein:
5322018
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

biological source

Saccharomyces cerevisiae

Assay

≥99%

form

powder

optical activity

[α]20/D 174 to 182 °, c = 7% (w/v) in water

technique(s)

HPLC: suitable
PCR: suitable
cell based assay: suitable
cryopreservation: suitable

impurities

≤5.0% EtOH
<20 ppm Trace metals

color

white

mp

97-99  °C

solubility

water: 50 mg/mL, clear, colorless

application(s)

advanced drug delivery
agriculture
cell analysis
life science and biopharma
sample preparation

storage temp.

room temp

SMILES string

[H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1

InChI key

DPVHGFAJLZWDOC-PVXXTIHASA-N

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1 of 4

This Item
T525190210T0167
D-(+)-Trehalose dihydrate suitable for microbiology, &#8805;99.0%, composed of two &#945;-glucose units that is used as a protectant, stabilizer and to support proper folding

Millipore

90210

D-(+)-Trehalose dihydrate

assay

≥99%

assay

≥98.5% (HPLC)

assay

≥99.0% (HPLC)

assay

≥99%

form

powder

form

powder

form

powder

form

powder

technique(s)

HPLC: suitable, PCR: suitable, cell based assay: suitable, cryopreservation: suitable

technique(s)

HPLC: suitable, cryopreservation: suitable

technique(s)

-

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

impurities

≤5.0% EtOH, <20 ppm Trace metals

impurities

-

impurities

≤0.1% glucose

impurities

-

color

white

color

-

color

-

color

-

General description

Trehalose, also known as mycose or tremalose, is a nonreducing disaccharide of glucose commonly found in fungi, bacteria, and invertebrates. Its presence in these organisms highlights its significance in various biological processes and potential applications in biochemical research and cell culture studies.

Application

D-(+)-Trehalose dihydrate has been used:

  • as a transcription factor EB (TFEB) to study its effects on an autophagy-lysosomal system in human silicosis alveolar macrophages
  • as stabilizing excipient in spray-dried protein formulations
  • as a cryoprotectant to study its effects on mouse testicular cell suspensions

Biochem/physiol Actions

D-(+)-Trehalose shows anti-desiccant and cryopreservative activities. It acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon. Trehalose is involved in the food, cosmetic, and pharmaceutical industries. It plays a vital role in the survival of certain insects and plants known as anhydrobionts during harsh environments such as high rates of dehydration.

Quality

Reduced metal ion content.

Preparation Note

Prepared by ion exchange chromatography.

Other Notes

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Customers Also Viewed

Slide 1 of 5

1 of 5

Trehalose metabolism in plants
Lunn J E, et al.
The Plant Journal, 79(4), 544-567 (2014)
Trehalose production: exploiting novel approaches
Schiraldi C, et al.
Trends in Biotechnology, 20(10), 420- 425 (2002)
Trehalose: current use and future applications
Ohtake S and Wang Y J
Journal of Pharmaceutical Sciences, 100(6) , 2020-2053 (2011)
Shiyi Tan et al.
Life sciences, 257, 118043-118043 (2020-07-06)
Alveolar macrophages (AMs) are the primary targets of silicosis. Blockade of autophagy may aggravate the apoptosis of AMs. Trehalose (Tre), a transcription factor EB (TFEB) activator, may impact the autophagy-lysosomal system in AMs during silicosis. However, the mechanism by which
Tiina Lipiäinen et al.
International journal of pharmaceutics, 543(1-2), 21-28 (2018-03-24)
Spray-dried protein formulations commonly require stabilising excipients to prevent protein degradation during processing and storage, and trehalose has been commonly used. The purpose of this work was to evaluate melibiose in spray-dried protein formulations in comparison to trehalose. The protein-activity-preserving

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