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UC448

Sigma-Aldrich

Paracetamol sulfate potassium salt

solid, ≥97% (HPLC)

Synonym(s):

4-Acetamidophenol sulfate ester potassium salt, Acetaminophen sulfate potassium salt, N-(4-Sulfoxyphenyl)acetamide monopotassium salt

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About This Item

Empirical Formula (Hill Notation):
C8H8KNO5S
CAS Number:
Molecular Weight:
269.32
MDL number:
UNSPSC Code:
12161501
PubChem Substance ID:
NACRES:
NA.77

assay

≥97% (HPLC)

form

solid

color

white to off-white

mp

163 °C

solubility

H2O: soluble

storage temp.

2-8°C

SMILES string

[K+].CC(=O)Nc1ccc(OS([O-])(=O)=O)cc1

InChI

1S/C8H9NO5S.K/c1-6(10)9-7-2-4-8(5-3-7)14-15(11,12)13;/h2-5H,1H3,(H,9,10)(H,11,12,13);/q;+1/p-1

InChI key

AJYPYWFCUWHZMZ-UHFFFAOYSA-M

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General description

Paracetamol is an aminophenol derivative. It functions as an analgesic and antipyretic drug, which has weak inflammatory effect. Paracetamol is used to treat pyrexia and mild to moderate pain. It might inhibit atherosclerosis through its antioxidant activity.

Application

Paracetamol sulfate potassium salt has been used as a standard for HPLC assays of acetaminophen.

Biochem/physiol Actions

Phase II metabolite of paracetamol.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

Paracetamol sulfate potassium salt is soluble in water.

Other Notes

Occasionally, it may be necessary to supply as the sodium salt

pictograms

CorrosionExclamation mark

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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D Bougie et al.
Blood, 97(12), 3846-3850 (2001-06-05)
In patients suspected of having drug-induced immune thrombocytopenia, antibodies reactive with normal platelets in the presence of the suspect drug can sometimes be identified, but negative results are often obtained. One reason for this is that drug metabolites, formed in
Paracetamol: past, present, and future.
Prescott LF
American Journal of Therapeutics, 7(2), 143-147 (2000)
Concise Clinical Pharmacology (2007)
Hayati Filik et al.
Chemical & pharmaceutical bulletin, 54(6), 891-896 (2006-06-07)
In the present paper, conventional spectrophotometry in conjunction with cloud point extraction-preconcentration were investigated as alternative methods for paracetamol (PCT) assay in urine samples. Cloud point extraction (CPE) was employed for the preconcentration of p-aminophenol (PAP) prior to spectrophotometric determination
H Xiong et al.
The Journal of pharmacology and experimental therapeutics, 295(2), 512-518 (2000-10-25)
Previous studies have demonstrated that phenobarbital treatment impairs the biliary excretion of acetaminophen glucuronide (AG), although the transport system(s) responsible for AG excretion into bile has not been identified. Initial studies in rat canalicular liver plasma membrane vesicles indicated that

Articles

Human epithelial intestinal colonic organoids can be used as an alternative to Caco-2 drug permeability assays for drug screening and compound toxicity testing.

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