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1029002

USP

Amitriptyline hydrochloride

United States Pharmacopeia (USP) Reference Standard

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About This Item

Empirical Formula (Hill Notation):
C20H23N · HCl
CAS Number:
549-18-8
Molecular Weight:
313.86
MDL number:
MFCD00012537
UNSPSC Code:
41116107
PubChem Substance ID:
329749005
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

amitriptyline

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

InChI key

KFYRPLNVJVHZGT-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530) , SLC6A4(6532)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Amitriptyline hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Amitriptyline Hydrochloride Tablets
  • Chlordiazepoxide and Amitriptyline Hydrochloride Tablets
  • Cyclobenzaprine Hydrochloride Extended-Release Capsules
  • Perphenazine and Amitriptyline Hydrochloride Tablets

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Related product

Product No.
Description
Pricing

D1000000

Dibenzosuberone, European Pharmacopoeia (EP) Reference Standard

Y0000563

Amitriptyline hydrochloride, European Pharmacopoeia (EP) Reference Standard

1029013

Amitriptyline Related Compound A, United States Pharmacopeia (USP) Reference Standard

1029024

Amitriptyline Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1776

Amitriptyline Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

BP016

Amitriptyline hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP858

Dibenzosuberone, British Pharmacopoeia (BP) Reference Standard

PHR2836

Amitriptyline Related Compound A, certified reference material, pharmaceutical secondary standard

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Katja Kovacic et al.
The Journal of pediatrics, 164(5), 1104-1109 (2014-03-13)
To compare children with primary, chronic idiopathic nausea to those with secondary nausea associated with functional abdominal pain. Retrospective chart review of 45 children with a primary complaint of chronic nausea several times per week. Comparisons were made to prospectively
Mariola Herbet et al.
Acta poloniae pharmaceutica, 70(5), 913-917 (2013-10-24)
The aim of the present study was to assess the impact of combined therapy with rosuvastatin (10 mg/kg) and amitriptyline (10 mg/kg) on oxidation-reduction status in the blood of rats. After 2-week application of drugs alone or their combination, the
Jennifer S Gewandter et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 22(7), 1807-1814 (2014-02-18)
Chemotherapy-induced peripheral neuropathy (CIPN) occurs in as high as 70% of patients receiving certain types of chemotherapy agents. The FDA has yet to approve a therapy for CIPN. The aim of this multicenter, phase III, randomized, double-blind, placebo-controlled trial was
Grzegorz Jagla et al.
Pharmacological reports : PR, 66(3), 459-465 (2014-06-07)
The therapy of neuropathic pain may include the use of co-analgesics, such as antidepressants, however, their desired analgesic effect is associated with significant side effects. An alternative approach to this is their local administration which has been proposed, but there
Ming Yang et al.
Aquatic toxicology (Amsterdam, Netherlands), 151, 68-76 (2014-01-23)
Amitriptyline is a tricyclic antidepressant used for decades. It is present at low detectable concentrations in the aquatic environment, but relative few studies have focused on its ecotoxicological effects on non-target aquatic animals. The present study conducted an acute toxicity
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