Skip to Content
MilliporeSigma
  • Changes in the viscoelastic properties of cortical bone by selective degradation of matrix protein.

Changes in the viscoelastic properties of cortical bone by selective degradation of matrix protein.

Journal of biomechanics (2012-12-25)
Hideki Shirakawa, Kazuya Furusawa, Akimasa Fukui, Shigeru Tadano, Naoki Sasaki
ABSTRACT

We have studied stress relaxation of bovine femoral cortical bone specimens treated with KOH aqueous solution which had been known to degrade selectively protein molecules in bone. With the KOH treatment, we found an increase in specimens' volume. This increase was regarded as swelling of the bone specimen, presumably due to matrix protein network degradation including that of collagen. In an analogy of bone to gel structure, an increasing ratio of specimen volume was used as an indicating parameter for the matrix protein network degradation by the treatment. Although an empirical equation with a linearly combined form of two Kohlrausch-Williams-Watts (KWW) functions has been shown to describe the stress relaxation of bone specimens, a single KWW function was suitable for the bone specimens treated with KOH solution for as little as 3h. In KOH treated specimens, both the initial modulus and the relaxation time decreased with the volume-increasing ratio, while the relaxation time distribution did not change. A chemo-rheological consideration attributed the reduction of modulus values to the network degradation in the organic matrix phase. The relaxation time of KOH treated specimens was thought to be related to the longer relaxation time of untreated bones, although there was a discontinuity between the extrapolated relaxation time values for KOH treated specimens and untreated specimens. This discontinuity may have originated from the release of residual stress existing in the bone by the matrix protein degradation. The results of the present study suggest that the state of matrix protein is crucial for integrating the mechanical properties of bone.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
trans-4-Hydroxy-L-proline, ≥99%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
trans-4-Hydroxy-L-proline, BioReagent, suitable for cell culture, ≥98.5%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
trans-4-Hydroxy-L-proline, BioXtra, ≥99.0% (NT)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Supelco
Potassium hydroxide concentrate, 0.1 M KOH in water (0.1N), Eluent concentrate for IC
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Supelco
trans-4-Hydroxy-L-proline, analytical standard
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide, tested according to Ph. Eur.
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide solution, 0.1 M in ethanol
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide solution, 0.5 M in ethanol
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide solution, 0.02 M in ethanol
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide solution, 1 M
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide solution, 0.5 M
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide solution, 0.1 M
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide solution, 0.1 M in isopropanol
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Supelco
Potassium hydroxide solution, volumetric, 8.0 M KOH (8.0N)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide, ≥85% KOH basis, pellets, white
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide solution, 45 wt. % in H2O
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide, puriss. p.a., ≥86% (T), pellets
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide, semiconductor grade, pellets, 99.99% trace metals basis (Purity excludes sodium content.)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide, reagent grade, 90%, flakes
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide, pellets, reag. Ph. Eur., ≥85%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide, ACS reagent, ≥85%, pellets
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide, BioXtra, ≥85% KOH basis
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide, free-flowing, Redi-Dri, ACS reagent, ≥85%, pellets
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide, puriss., meets analytical specification of Ph. Eur., BP, 85-100.5%, pellets
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00
Sigma-Aldrich
Potassium hydroxide, technical, ≥85%, powder
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
In Stock
$429.00