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Solid lipid nanoparticles of anticancer drug andrographolide: formulation, in vitro and in vivo studies.

Solid lipid nanoparticles of anticancer drug andrographolide: formulation, in vitro and in vivo studies.

Drug development and industrial pharmacy (2013-07-06)

Rabea Parveen, F J Ahmad, Z Iqbal, M Samim, Sayeed Ahmad

ABSTRACT

Diterpenoidal anti-cancer drug andrographolide (AD) was encapsulated into solid lipid nanoparticle (SLN) because of poor aqueous solubility and high lipophilicity. AD-SLNs were prepared by solvent injection method and characterized for droplet size, surface morphology, zeta potential, etc. In vitro drug release was carried out by dialysis-membrane method. A pharmacokinetic study was performed by UPLC/Q-TOF-MS method to determine the maximum plasma concentration (Cmax), area under the curve (AUC), etc. There was an improvement in Cmax and AUC of AD-SLNs when compared with AD, thereby enhancing the bioavailability of AD. The tmax was increased than that of AD suspension, indicating the sustained release pattern of AD-SLNs. The antitumor activity was carried out on Balb/c mice showing better results with AD-SLNs as compared to AD. Thus, the AD-loaded SLNs would be useful for delivering poorly water-soluble AD with enhanced bioavailability and improved antitumor activity.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

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