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  • Dapper-1 is essential for Wnt5a induced cardiomyocyte hypertrophy by regulating the Wnt/PCP pathway.

Dapper-1 is essential for Wnt5a induced cardiomyocyte hypertrophy by regulating the Wnt/PCP pathway.

FEBS letters (2014-06-01)
Marco Hagenmueller, Johannes H Riffel, Elmar Bernhold, Jingjing Fan, Hugo A Katus, Stefan E Hardt
ABSTRACT

The Wnt signaling pathway was identified as crucial mediator of cardiomyocyte hypertrophy. In this study we found that activation of non-canonical Wnt signaling by Wnt5a stimulates protein synthesis and enlargement of cardiomyocyte surface area. These hypertrophic features were inhibited in Dapper-1 (Dpr1) depleted cells. On the molecular level, we observed inhibition of the non-canonical Wnt/planar-cell-polarity (PCP) pathway denoted by reduction of c-jun-n-terminal-kinase (JNK) phosphorylation. Upstream of JNK, increased protein levels of the Wnt/PCP trans-membrane receptor van-Gogh-like-2 (Vangl2) were observed along with an enrichment of Vangl2 in perinuclear located vesicles. The findings suggest that Dpr1 is essential for execution of the Wnt/PCP pathway and regulation of the Vangl2/JNK axis. Depletion of Dpr1 inhibits non-canonical Wnt signaling induced cardiomyocyte hypertrophy by blocking Wnt/PCP signaling.

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Formaldehyde solution, for molecular biology, BioReagent, ≥36.0% in H2O (T)
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Formaldehyde solution, meets analytical specification of USP, ≥34.5 wt. %
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10 mg
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Formaldehyde solution, tested according to Ph. Eur.
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Formaldehyde solution, ACS reagent, 37 wt. % in H2O, contains 10-15% Methanol as stabilizer (to prevent polymerization)
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Formaldehyde-12C solution, 20% in H2O, 99.9 atom % 12C
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Formaldehyde solution, for molecular biology, 36.5-38% in H2O
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Supelco
Formaldehyde solution, stabilized with methanol, ~37 wt. % in H2O, certified reference material
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$161.00
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Formaldehyde solution, JIS special grade, 36.0-38.0%, contains methanol as stabilizer
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10 mg
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Formaldehyde solution, 10%
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Formaldehyde solution, SAJ first grade, ≥35.0%, contains methanol as stabilizer
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SAFC
Formaldehyde solution, contains 10-15% methanol as stabilizer, 37 wt. % in H2O
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$161.00